Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Puma genomes from North and South America provide insights into the genomic consequences of inbreeding. / Saremi, Nedda F.; Supple, Megan A.; Byrne, Ashley; Cahill, James A.; Coutinho, Luiz Lehmann; Dalén, Love; Figueiró, Henrique V.; Johnson, Warren E.; Milne, Heather J.; O’Brien, Stephen J.; O’Connell, Brendan; Onorato, David P.; Riley, Seth P.D.; Sikich, Jeff A.; Stahler, Daniel R.; Villela, Priscilla Marqui Schmidt; Vollmers, Christopher; Wayne, Robert K.; Eizirik, Eduardo; Corbett-Detig, Russell B.; Green, Richard E.; Wilmers, Christopher C.; Shapiro, Beth.
в: Nature Communications, Том 10, № 1, 4769, 18.10.2019.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Puma genomes from North and South America provide insights into the genomic consequences of inbreeding
AU - Saremi, Nedda F.
AU - Supple, Megan A.
AU - Byrne, Ashley
AU - Cahill, James A.
AU - Coutinho, Luiz Lehmann
AU - Dalén, Love
AU - Figueiró, Henrique V.
AU - Johnson, Warren E.
AU - Milne, Heather J.
AU - O’Brien, Stephen J.
AU - O’Connell, Brendan
AU - Onorato, David P.
AU - Riley, Seth P.D.
AU - Sikich, Jeff A.
AU - Stahler, Daniel R.
AU - Villela, Priscilla Marqui Schmidt
AU - Vollmers, Christopher
AU - Wayne, Robert K.
AU - Eizirik, Eduardo
AU - Corbett-Detig, Russell B.
AU - Green, Richard E.
AU - Wilmers, Christopher C.
AU - Shapiro, Beth
PY - 2019/10/18
Y1 - 2019/10/18
N2 - Pumas are the most widely distributed felid in the Western Hemisphere. Increasingly, however, human persecution and habitat loss are isolating puma populations. To explore the genomic consequences of this isolation, we assemble a draft puma genome and a geographically broad panel of resequenced individuals. We estimate that the lineage leading to present-day North American pumas diverged from South American lineages 300–100 thousand years ago. We find signatures of close inbreeding in geographically isolated North American populations, but also that tracts of homozygosity are rarely shared among these populations, suggesting that assisted gene flow would restore local genetic diversity. The genome of a Florida panther descended from translocated Central American individuals has long tracts of homozygosity despite recent outbreeding. This suggests that while translocations may introduce diversity, sustaining diversity in small and isolated populations will require either repeated translocations or restoration of landscape connectivity. Our approach provides a framework for genome-wide analyses that can be applied to the management of similarly small and isolated populations.
AB - Pumas are the most widely distributed felid in the Western Hemisphere. Increasingly, however, human persecution and habitat loss are isolating puma populations. To explore the genomic consequences of this isolation, we assemble a draft puma genome and a geographically broad panel of resequenced individuals. We estimate that the lineage leading to present-day North American pumas diverged from South American lineages 300–100 thousand years ago. We find signatures of close inbreeding in geographically isolated North American populations, but also that tracts of homozygosity are rarely shared among these populations, suggesting that assisted gene flow would restore local genetic diversity. The genome of a Florida panther descended from translocated Central American individuals has long tracts of homozygosity despite recent outbreeding. This suggests that while translocations may introduce diversity, sustaining diversity in small and isolated populations will require either repeated translocations or restoration of landscape connectivity. Our approach provides a framework for genome-wide analyses that can be applied to the management of similarly small and isolated populations.
KW - gene flow
KW - genetic analysis
KW - Genome
KW - genomics
KW - habitat loss
KW - inbreeding
KW - Landscape
KW - POPULATION HISTORY
KW - PATTERNS
KW - MITOCHONDRIAL-DNA
KW - INFERENCE
KW - GENE FLOW
KW - HOMOZYGOSITY
KW - DISPERSAL
KW - EVOLUTION
KW - DYNAMICS
KW - FLORIDA
UR - http://www.scopus.com/inward/record.url?scp=85073622174&partnerID=8YFLogxK
U2 - 10.1038/s41467-019-12741-1
DO - 10.1038/s41467-019-12741-1
M3 - Article
C2 - 31628318
AN - SCOPUS:85073622174
VL - 10
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 4769
ER -
ID: 49510315