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Puma genomes from North and South America provide insights into the genomic consequences of inbreeding. / Saremi, Nedda F.; Supple, Megan A.; Byrne, Ashley; Cahill, James A.; Coutinho, Luiz Lehmann; Dalén, Love; Figueiró, Henrique V.; Johnson, Warren E.; Milne, Heather J.; O’Brien, Stephen J.; O’Connell, Brendan; Onorato, David P.; Riley, Seth P.D.; Sikich, Jeff A.; Stahler, Daniel R.; Villela, Priscilla Marqui Schmidt; Vollmers, Christopher; Wayne, Robert K.; Eizirik, Eduardo; Corbett-Detig, Russell B.; Green, Richard E.; Wilmers, Christopher C.; Shapiro, Beth.

In: Nature Communications, Vol. 10, No. 1, 4769, 18.10.2019.

Research output: Contribution to journal › Article › peer-review

Harvard

Saremi, NF, Supple, MA, Byrne, A, Cahill, JA, Coutinho, LL, Dalén, L, Figueiró, HV, Johnson, WE, Milne, HJ, O’Brien, SJ, O’Connell, B, Onorato, DP, Riley, SPD, Sikich, JA, Stahler, DR, Villela, PMS, Vollmers, C, Wayne, RK, Eizirik, E, Corbett-Detig, RB, Green, RE, Wilmers, CC & Shapiro, B 2019, 'Puma genomes from North and South America provide insights into the genomic consequences of inbreeding', Nature Communications, vol. 10, no. 1, 4769. https://doi.org/10.1038/s41467-019-12741-1

APA

Saremi, N. F., Supple, M. A., Byrne, A., Cahill, J. A., Coutinho, L. L., Dalén, L., Figueiró, H. V., Johnson, W. E., Milne, H. J., O’Brien, S. J., O’Connell, B., Onorato, D. P., Riley, S. P. D., Sikich, J. A., Stahler, D. R., Villela, P. M. S., Vollmers, C., Wayne, R. K., Eizirik, E., ... Shapiro, B. (2019). Puma genomes from North and South America provide insights into the genomic consequences of inbreeding. Nature Communications, 10(1), [4769]. https://doi.org/10.1038/s41467-019-12741-1

Vancouver

Saremi NF, Supple MA, Byrne A, Cahill JA, Coutinho LL, Dalén L et al. Puma genomes from North and South America provide insights into the genomic consequences of inbreeding. Nature Communications. 2019 Oct 18;10(1). 4769. https://doi.org/10.1038/s41467-019-12741-1

Author

Saremi, Nedda F. ; Supple, Megan A. ; Byrne, Ashley ; Cahill, James A. ; Coutinho, Luiz Lehmann ; Dalén, Love ; Figueiró, Henrique V. ; Johnson, Warren E. ; Milne, Heather J. ; O’Brien, Stephen J. ; O’Connell, Brendan ; Onorato, David P. ; Riley, Seth P.D. ; Sikich, Jeff A. ; Stahler, Daniel R. ; Villela, Priscilla Marqui Schmidt ; Vollmers, Christopher ; Wayne, Robert K. ; Eizirik, Eduardo ; Corbett-Detig, Russell B. ; Green, Richard E. ; Wilmers, Christopher C. ; Shapiro, Beth. / Puma genomes from North and South America provide insights into the genomic consequences of inbreeding. In: Nature Communications. 2019 ; Vol. 10, No. 1.

BibTeX

@article{3d7f3f1c8e104bb09227869ca837583a,
title = "Puma genomes from North and South America provide insights into the genomic consequences of inbreeding",
abstract = "Pumas are the most widely distributed felid in the Western Hemisphere. Increasingly, however, human persecution and habitat loss are isolating puma populations. To explore the genomic consequences of this isolation, we assemble a draft puma genome and a geographically broad panel of resequenced individuals. We estimate that the lineage leading to present-day North American pumas diverged from South American lineages 300–100 thousand years ago. We find signatures of close inbreeding in geographically isolated North American populations, but also that tracts of homozygosity are rarely shared among these populations, suggesting that assisted gene flow would restore local genetic diversity. The genome of a Florida panther descended from translocated Central American individuals has long tracts of homozygosity despite recent outbreeding. This suggests that while translocations may introduce diversity, sustaining diversity in small and isolated populations will require either repeated translocations or restoration of landscape connectivity. Our approach provides a framework for genome-wide analyses that can be applied to the management of similarly small and isolated populations.",
keywords = "gene flow, genetic analysis, Genome, genomics, habitat loss, inbreeding, Landscape, POPULATION HISTORY, PATTERNS, MITOCHONDRIAL-DNA, INFERENCE, GENE FLOW, HOMOZYGOSITY, DISPERSAL, EVOLUTION, DYNAMICS, FLORIDA",
author = "Saremi, {Nedda F.} and Supple, {Megan A.} and Ashley Byrne and Cahill, {James A.} and Coutinho, {Luiz Lehmann} and Love Dal{\'e}n and Figueir{\'o}, {Henrique V.} and Johnson, {Warren E.} and Milne, {Heather J.} and O{\textquoteright}Brien, {Stephen J.} and Brendan O{\textquoteright}Connell and Onorato, {David P.} and Riley, {Seth P.D.} and Sikich, {Jeff A.} and Stahler, {Daniel R.} and Villela, {Priscilla Marqui Schmidt} and Christopher Vollmers and Wayne, {Robert K.} and Eduardo Eizirik and Corbett-Detig, {Russell B.} and Green, {Richard E.} and Wilmers, {Christopher C.} and Beth Shapiro",
year = "2019",
month = oct,
day = "18",
doi = "10.1038/s41467-019-12741-1",
language = "English",
volume = "10",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Puma genomes from North and South America provide insights into the genomic consequences of inbreeding

AU - Saremi, Nedda F.

AU - Supple, Megan A.

AU - Byrne, Ashley

AU - Cahill, James A.

AU - Coutinho, Luiz Lehmann

AU - Dalén, Love

AU - Figueiró, Henrique V.

AU - Johnson, Warren E.

AU - Milne, Heather J.

AU - O’Brien, Stephen J.

AU - O’Connell, Brendan

AU - Onorato, David P.

AU - Riley, Seth P.D.

AU - Sikich, Jeff A.

AU - Stahler, Daniel R.

AU - Villela, Priscilla Marqui Schmidt

AU - Vollmers, Christopher

AU - Wayne, Robert K.

AU - Eizirik, Eduardo

AU - Corbett-Detig, Russell B.

AU - Green, Richard E.

AU - Wilmers, Christopher C.

AU - Shapiro, Beth

PY - 2019/10/18

Y1 - 2019/10/18

N2 - Pumas are the most widely distributed felid in the Western Hemisphere. Increasingly, however, human persecution and habitat loss are isolating puma populations. To explore the genomic consequences of this isolation, we assemble a draft puma genome and a geographically broad panel of resequenced individuals. We estimate that the lineage leading to present-day North American pumas diverged from South American lineages 300–100 thousand years ago. We find signatures of close inbreeding in geographically isolated North American populations, but also that tracts of homozygosity are rarely shared among these populations, suggesting that assisted gene flow would restore local genetic diversity. The genome of a Florida panther descended from translocated Central American individuals has long tracts of homozygosity despite recent outbreeding. This suggests that while translocations may introduce diversity, sustaining diversity in small and isolated populations will require either repeated translocations or restoration of landscape connectivity. Our approach provides a framework for genome-wide analyses that can be applied to the management of similarly small and isolated populations.

AB - Pumas are the most widely distributed felid in the Western Hemisphere. Increasingly, however, human persecution and habitat loss are isolating puma populations. To explore the genomic consequences of this isolation, we assemble a draft puma genome and a geographically broad panel of resequenced individuals. We estimate that the lineage leading to present-day North American pumas diverged from South American lineages 300–100 thousand years ago. We find signatures of close inbreeding in geographically isolated North American populations, but also that tracts of homozygosity are rarely shared among these populations, suggesting that assisted gene flow would restore local genetic diversity. The genome of a Florida panther descended from translocated Central American individuals has long tracts of homozygosity despite recent outbreeding. This suggests that while translocations may introduce diversity, sustaining diversity in small and isolated populations will require either repeated translocations or restoration of landscape connectivity. Our approach provides a framework for genome-wide analyses that can be applied to the management of similarly small and isolated populations.

KW - gene flow

KW - genetic analysis

KW - Genome

KW - genomics

KW - habitat loss

KW - inbreeding

KW - Landscape

KW - POPULATION HISTORY

KW - PATTERNS

KW - MITOCHONDRIAL-DNA

KW - INFERENCE

KW - GENE FLOW

KW - HOMOZYGOSITY

KW - DISPERSAL

KW - EVOLUTION

KW - DYNAMICS

KW - FLORIDA

UR - http://www.scopus.com/inward/record.url?scp=85073622174&partnerID=8YFLogxK

U2 - 10.1038/s41467-019-12741-1

DO - 10.1038/s41467-019-12741-1

M3 - Article

C2 - 31628318

AN - SCOPUS:85073622174

VL - 10

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 4769

ER -

ID: 49510315