TY - CONF

T1 - Psychophysiological mechanisms features of events sequences predicting in schizophrenia depending on neuroleptics different types

AU - Горбунов, Иван Анатольевич

AU - Чепикова, Карина Андреевна

AU - Яничев, Дмитрий Павлович

AU - Гаевский, Александр

N1 - Conference code: 19

PY - 2018/9/5

Y1 - 2018/9/5

N2 - The ability of brain to forecast a future events is one of the important cognitive ability. According by Karl Friston (FristonK.,2003) it plays the basic role in learning and adaptation to environmental changes. The ability to adapt is known to bereduced in patients with schizophrenia. The reason for this may be the inability of schizophrenic patients to learn effectivelyand, thus, the inability to forecast environmental changes. In studies of the brain’s predictive ability by registration the MMNand P300 response to the standard and deviant (unexpected) stimuli differences were found in responses by schizophrenicand healthy subjects (Umbricht et al.2003). In schizophrenia, these studies demonstrated deficits in MMN and P300generation, but some studies failed to confirm it (Michie 2001).We investigated the neurophysiological mechanisms of cognitive functions associated with parameters of various cognitivestyles. As subjects, we invited schizophrenic patients with paranoid seizures and healthy people with different cognitivestyles. Schizophrenic patients were also divided into groups, depending on what neuroleptics they were taking. We usedpsychological methods to measure cognitive styles and method of assessing negative symptoms at schizophrenia (SANS).To assess the functioning of neurophysiological mechanisms of cognitive functions, the evoked potentials for variousstandard and deviant stimuli arranget in sequences were used. In the instruction we asked to count the number of stimulithat regularly change according to a certain rule (for example increase in the sound frequency). We considered differencesin brain responses to deviant and standard stimuli in terms of the parameter given in the instructions, as well as differencesbetween the responses to deviant and standard stimuli according to a parameter not specified in the instruction. Forschizophrenic patients, changes in the work of neurophysiological mechanisms of cognitive functions, reflected in the EPand in the visualization of the work of the hippocampal structures were found. This effect can be associated withmechanisms of translation from short-term to long-term memory, through changes of synapses potency of neurons duringtraining to predict changes in sequences. These mechanisms depend on cognitive styles and reception different types ofneuroleptics

AB - The ability of brain to forecast a future events is one of the important cognitive ability. According by Karl Friston (FristonK.,2003) it plays the basic role in learning and adaptation to environmental changes. The ability to adapt is known to bereduced in patients with schizophrenia. The reason for this may be the inability of schizophrenic patients to learn effectivelyand, thus, the inability to forecast environmental changes. In studies of the brain’s predictive ability by registration the MMNand P300 response to the standard and deviant (unexpected) stimuli differences were found in responses by schizophrenicand healthy subjects (Umbricht et al.2003). In schizophrenia, these studies demonstrated deficits in MMN and P300generation, but some studies failed to confirm it (Michie 2001).We investigated the neurophysiological mechanisms of cognitive functions associated with parameters of various cognitivestyles. As subjects, we invited schizophrenic patients with paranoid seizures and healthy people with different cognitivestyles. Schizophrenic patients were also divided into groups, depending on what neuroleptics they were taking. We usedpsychological methods to measure cognitive styles and method of assessing negative symptoms at schizophrenia (SANS).To assess the functioning of neurophysiological mechanisms of cognitive functions, the evoked potentials for variousstandard and deviant stimuli arranget in sequences were used. In the instruction we asked to count the number of stimulithat regularly change according to a certain rule (for example increase in the sound frequency). We considered differencesin brain responses to deviant and standard stimuli in terms of the parameter given in the instructions, as well as differencesbetween the responses to deviant and standard stimuli according to a parameter not specified in the instruction. Forschizophrenic patients, changes in the work of neurophysiological mechanisms of cognitive functions, reflected in the EPand in the visualization of the work of the hippocampal structures were found. This effect can be associated withmechanisms of translation from short-term to long-term memory, through changes of synapses potency of neurons duringtraining to predict changes in sequences. These mechanisms depend on cognitive styles and reception different types ofneuroleptics

KW - ERP

KW - Scizophrenia

KW - attention

KW - neuroleptics

U2 - 10.1016/j.ijpsycho.2018.07.230

DO - 10.1016/j.ijpsycho.2018.07.230

M3 - Abstract

SP - 24

Y2 - 4 September 2018 through 8 September 2018

ER -