Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Photoswitchable Phosphonate–Fullerene Hybrids with Cholinesterase Activity. / Kolesnikov, Ilya; Mamonova, Daria; Pankin, Dmitrii; Bikbaeva, Gulia; Khokhlova, Anastasia; Pilip, Anna; Egorova, Anastasia; Zigel, Vladislav; Manshina, Alina.
в: Photochemistry and Photobiology, 17.09.2022.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Photoswitchable Phosphonate–Fullerene Hybrids with Cholinesterase Activity
AU - Kolesnikov, Ilya
AU - Mamonova, Daria
AU - Pankin, Dmitrii
AU - Bikbaeva, Gulia
AU - Khokhlova, Anastasia
AU - Pilip, Anna
AU - Egorova, Anastasia
AU - Zigel, Vladislav
AU - Manshina, Alina
N1 - Publisher Copyright: © 2022 American Society for Photobiology.
PY - 2022/9/17
Y1 - 2022/9/17
N2 - Modern progress in photopharmocology calls for new generation of compounds joining bioactivity, photoswitchable properties and high selectivity of response to light wavelength. Introduced here, phosphonate–fullerene hybrids are the first representatives of such compounds. Phosphonate–fullerene hybrids were synthesized on a base of fullerene C60 and organophosphates with the function of photoswitchable cholinesterase activity—phosphorylated thiazolotriazole and aminomalonate compounds and studied with FTIR, UV–VIS spectroscopy and IPC-micro neurotoxin amperometric analysis. As a result of spectroscopic and bioactivity characterization, it was not only demonstrated butyrylcholinesterase (BuChE) inhibition increase in phosphonate–fullerene hybrids compared with pure phosphonates but also pronounced response of inhibition degree to laser irradiation of hybrids. It was found opposite behavior of hybrids as a result of laser irradiation—BuChE inhibition drop-off for thiazolotriazole–fullerene and pronounced growth for aminomalonate–fullerene. The other remarkable peculiarity of presented phosphonate–fullerene hybrids is high selectivity of inhibition change degree to laser wavelength (266 or 325 nm).
AB - Modern progress in photopharmocology calls for new generation of compounds joining bioactivity, photoswitchable properties and high selectivity of response to light wavelength. Introduced here, phosphonate–fullerene hybrids are the first representatives of such compounds. Phosphonate–fullerene hybrids were synthesized on a base of fullerene C60 and organophosphates with the function of photoswitchable cholinesterase activity—phosphorylated thiazolotriazole and aminomalonate compounds and studied with FTIR, UV–VIS spectroscopy and IPC-micro neurotoxin amperometric analysis. As a result of spectroscopic and bioactivity characterization, it was not only demonstrated butyrylcholinesterase (BuChE) inhibition increase in phosphonate–fullerene hybrids compared with pure phosphonates but also pronounced response of inhibition degree to laser irradiation of hybrids. It was found opposite behavior of hybrids as a result of laser irradiation—BuChE inhibition drop-off for thiazolotriazole–fullerene and pronounced growth for aminomalonate–fullerene. The other remarkable peculiarity of presented phosphonate–fullerene hybrids is high selectivity of inhibition change degree to laser wavelength (266 or 325 nm).
UR - http://www.scopus.com/inward/record.url?scp=85139263174&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/3097192d-4fb6-351e-a185-5e5dccc608a5/
U2 - 10.1111/php.13720
DO - 10.1111/php.13720
M3 - Article
AN - SCOPUS:85139263174
JO - Photochemistry and Photobiology
JF - Photochemistry and Photobiology
SN - 0031-8655
ER -
ID: 99551093