Photoswitchable Phosphonate–Fullerene Hybrids with Cholinesterase Activity

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Photoswitchable Phosphonate–Fullerene Hybrids with Cholinesterase Activity. / Kolesnikov, Ilya ; Mamonova, Daria; Pankin, Dmitrii; Bikbaeva, Gulia ; Khokhlova, Anastasia; Pilip, Anna; Egorova, Anastasia; Zigel, Vladislav; Manshina, Alina.

In: Photochemistry and Photobiology, 17.09.2022.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{aaa7a73b044e4daf977a95159786e8be,

title = "Photoswitchable Phosphonate–Fullerene Hybrids with Cholinesterase Activity",

abstract = "Modern progress in photopharmocology calls for new generation of compounds joining bioactivity, photoswitchable properties and high selectivity of response to light wavelength. Introduced here, phosphonate–fullerene hybrids are the first representatives of such compounds. Phosphonate–fullerene hybrids were synthesized on a base of fullerene C60 and organophosphates with the function of photoswitchable cholinesterase activity—phosphorylated thiazolotriazole and aminomalonate compounds and studied with FTIR, UV–VIS spectroscopy and IPC-micro neurotoxin amperometric analysis. As a result of spectroscopic and bioactivity characterization, it was not only demonstrated butyrylcholinesterase (BuChE) inhibition increase in phosphonate–fullerene hybrids compared with pure phosphonates but also pronounced response of inhibition degree to laser irradiation of hybrids. It was found opposite behavior of hybrids as a result of laser irradiation—BuChE inhibition drop-off for thiazolotriazole–fullerene and pronounced growth for aminomalonate–fullerene. The other remarkable peculiarity of presented phosphonate–fullerene hybrids is high selectivity of inhibition change degree to laser wavelength (266 or 325 nm).",

author = "Ilya Kolesnikov and Daria Mamonova and Dmitrii Pankin and Gulia Bikbaeva and Anastasia Khokhlova and Anna Pilip and Anastasia Egorova and Vladislav Zigel and Alina Manshina",

note = "Publisher Copyright: {\textcopyright} 2022 American Society for Photobiology.",

year = "2022",

month = sep,

day = "17",

doi = "10.1111/php.13720",

language = "English",

journal = "Photochemistry and Photobiology",

issn = "0031-8655",

publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Photoswitchable Phosphonate–Fullerene Hybrids with Cholinesterase Activity

AU - Kolesnikov, Ilya

AU - Mamonova, Daria

AU - Pankin, Dmitrii

AU - Bikbaeva, Gulia

AU - Khokhlova, Anastasia

AU - Pilip, Anna

AU - Egorova, Anastasia

AU - Zigel, Vladislav

AU - Manshina, Alina

PY - 2022/9/17

Y1 - 2022/9/17

N2 - Modern progress in photopharmocology calls for new generation of compounds joining bioactivity, photoswitchable properties and high selectivity of response to light wavelength. Introduced here, phosphonate–fullerene hybrids are the first representatives of such compounds. Phosphonate–fullerene hybrids were synthesized on a base of fullerene C60 and organophosphates with the function of photoswitchable cholinesterase activity—phosphorylated thiazolotriazole and aminomalonate compounds and studied with FTIR, UV–VIS spectroscopy and IPC-micro neurotoxin amperometric analysis. As a result of spectroscopic and bioactivity characterization, it was not only demonstrated butyrylcholinesterase (BuChE) inhibition increase in phosphonate–fullerene hybrids compared with pure phosphonates but also pronounced response of inhibition degree to laser irradiation of hybrids. It was found opposite behavior of hybrids as a result of laser irradiation—BuChE inhibition drop-off for thiazolotriazole–fullerene and pronounced growth for aminomalonate–fullerene. The other remarkable peculiarity of presented phosphonate–fullerene hybrids is high selectivity of inhibition change degree to laser wavelength (266 or 325 nm).

AB - Modern progress in photopharmocology calls for new generation of compounds joining bioactivity, photoswitchable properties and high selectivity of response to light wavelength. Introduced here, phosphonate–fullerene hybrids are the first representatives of such compounds. Phosphonate–fullerene hybrids were synthesized on a base of fullerene C60 and organophosphates with the function of photoswitchable cholinesterase activity—phosphorylated thiazolotriazole and aminomalonate compounds and studied with FTIR, UV–VIS spectroscopy and IPC-micro neurotoxin amperometric analysis. As a result of spectroscopic and bioactivity characterization, it was not only demonstrated butyrylcholinesterase (BuChE) inhibition increase in phosphonate–fullerene hybrids compared with pure phosphonates but also pronounced response of inhibition degree to laser irradiation of hybrids. It was found opposite behavior of hybrids as a result of laser irradiation—BuChE inhibition drop-off for thiazolotriazole–fullerene and pronounced growth for aminomalonate–fullerene. The other remarkable peculiarity of presented phosphonate–fullerene hybrids is high selectivity of inhibition change degree to laser wavelength (266 or 325 nm).

UR - http://www.scopus.com/inward/record.url?scp=85139263174&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/3097192d-4fb6-351e-a185-5e5dccc608a5/

U2 - 10.1111/php.13720

DO - 10.1111/php.13720

M3 - Article

AN - SCOPUS:85139263174

JO - Photochemistry and Photobiology

JF - Photochemistry and Photobiology

SN - 0031-8655

ER -

ID: 99551093