Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Phosphorylated flavonoids as selective carboxylesterase inhibitors. / Abzianidze, Victoria V. ; Prokofieva, Daria S. ; Beltyukov, Petr P. ; Kuznetsov, Victor A. ; Bogachenkov, Alexander S. ; Rodygin, Konstantin S. .
в: Mendeleev Communications, Том 29, № 1, 02.2019, стр. 61-63.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Phosphorylated flavonoids as selective carboxylesterase inhibitors
AU - Abzianidze, Victoria V.
AU - Prokofieva, Daria S.
AU - Beltyukov, Petr P.
AU - Kuznetsov, Victor A.
AU - Bogachenkov, Alexander S.
AU - Rodygin, Konstantin S.
PY - 2019/2
Y1 - 2019/2
N2 - A series of phosphorylated flavonoids has been synthesized and evaluated in vitro for inhibitory activity against carboxylesterase, acetylcholinesterase and butyrylcholinesterase as well as for their cytotoxicity towards human adenocarcinoma A549 and human glioblastoma U251 cell lines. Diethylphosphoryl derivatives of chrysin and 7-hydroxyflavone were found to be the most effective with bimolecular rate constants for carboxylesterase inhibition k i = 2.0 × 10 6 and 5.7 × 10 6 dm 3 mol −1 min −1 , respectively.
AB - A series of phosphorylated flavonoids has been synthesized and evaluated in vitro for inhibitory activity against carboxylesterase, acetylcholinesterase and butyrylcholinesterase as well as for their cytotoxicity towards human adenocarcinoma A549 and human glioblastoma U251 cell lines. Diethylphosphoryl derivatives of chrysin and 7-hydroxyflavone were found to be the most effective with bimolecular rate constants for carboxylesterase inhibition k i = 2.0 × 10 6 and 5.7 × 10 6 dm 3 mol −1 min −1 , respectively.
UR - http://www.scopus.com/inward/record.url?scp=85061545561&partnerID=8YFLogxK
U2 - 10.1016/j.mencom.2019.01.020
DO - 10.1016/j.mencom.2019.01.020
M3 - Article
VL - 29
SP - 61
EP - 63
JO - Mendeleev Communications
JF - Mendeleev Communications
SN - 0959-9436
IS - 1
ER -
ID: 36903742