Результаты исследований: Публикации в книгах, отчётах, сборниках, трудах конференций › статья в сборнике материалов конференции › научная › Рецензирование
One of the key advances in genome assembly that has led to a significant improvement in contig lengths has been utilization of paired reads (mate-pairs). While in most assemblers, mate-pair information is used in a post-processing step, the recently proposed Paired de Bruijn Graph (PDBG) approach incorporates the mate-pair information directly in the assembly graph structure. However, the PDBG approach faces difficulties when the variation in the insert sizes is high. To address this problem, we first transform mate-pairs into edge-pair histograms that allow one to better estimate the distance between edges in the assembly graph that represent regions linked by multiple mate-pairs. Further, we combine the ideas of mate-pair transformation and PDBGs to construct new data structures for genome assembly: pathsets and pathset graphs.
Язык оригинала | английский |
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Название основной публикации | Research in Computational Molecular Biology - 16th Annual International Conference, RECOMB 2012, Proceedings |
Страницы | 200-212 |
Число страниц | 13 |
DOI | |
Состояние | Опубликовано - 2012 |
Событие | 16th Annual International Conference on Research in Computational Molecular Biology - Barcelona, Испания Продолжительность: 21 апр 2012 → 24 апр 2012 |
Название | Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) |
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Том | 7262 LNBI |
ISSN (печатное издание) | 0302-9743 |
ISSN (электронное издание) | 1611-3349 |
конференция | 16th Annual International Conference on Research in Computational Molecular Biology |
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Сокращенное название | RECOMB 2012 |
Страна/Tерритория | Испания |
Город | Barcelona |
Период | 21/04/12 → 24/04/12 |
ID: 100630943