Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
One of the key advances in genome assembly that has led to a significant improvement in contig lengths has been utilization of paired reads (mate-pairs). While in most assemblers, mate-pair information is used in a post-processing step, the recently proposed Paired de Bruijn Graph (PDBG) approach incorporates the mate-pair information directly in the assembly graph structure. However, the PDBG approach faces difficulties when the variation in the insert sizes is high. To address this problem, we first transform mate-pairs into edge-pair histograms that allow one to better estimate the distance between edges in the assembly graph that represent regions linked by multiple mate-pairs. Further, we combine the ideas of mate-pair transformation and PDBGs to construct new data structures for genome assembly: pathsets and pathset graphs.
Original language | English |
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Title of host publication | Research in Computational Molecular Biology - 16th Annual International Conference, RECOMB 2012, Proceedings |
Pages | 200-212 |
Number of pages | 13 |
DOIs | |
State | Published - 2012 |
Event | 16th Annual International Conference on Research in Computational Molecular Biology - Barcelona, Spain Duration: 21 Apr 2012 → 24 Apr 2012 |
Name | Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) |
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Volume | 7262 LNBI |
ISSN (Print) | 0302-9743 |
ISSN (Electronic) | 1611-3349 |
Conference | 16th Annual International Conference on Research in Computational Molecular Biology |
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Abbreviated title | RECOMB 2012 |
Country/Territory | Spain |
City | Barcelona |
Period | 21/04/12 → 24/04/12 |
ID: 100630943