TY - JOUR

T1 - Ovarian tissue cryopreservation in prepubertal patients with oncological diseases

T2 - multidisciplinary approach and outcomes

AU - Dinikina, Yulia

AU - Belogurova, Margarita

AU - Zaritskey, Andrey

AU - Govorov, Igor

AU - Tsibizova, Valentina

AU - Gamzatova, Zaynab

AU - Pervunina, Tatyana

AU - Komlichenko, Eduard

N1 - Publisher Copyright: © 2019 Informa UK Limited, trading as Taylor & Francis Group.

PY - 2021/7/18

Y1 - 2021/7/18

N2 - In children with cancer, the issues related to the quality of life are becoming increasingly important together with the improvement of survival rates. This creates an entirely new challenge–minimizing the toxicity of the antitumor therapy without reducing its effectiveness. One of the specific side effects of the antitumor therapy is gonadotoxicity, which negatively affects both the somatic and mental state of the survivors. Since ovarian stimulation is ineffective in prepubertal patients, ovarian tissue cryopreservation (OTC) remains the most promising option to preserve fertility. The primary goal of this publication is to emphasize the importance of the reproductive health problem in girls with oncological diseases, with a description of the current data of international literature on the prospects of OTC in order to preserve fertility. Another goal is to present a multidisciplinary strategy for the management of prepubertal age patients with the oncological disease within the framework of the Oncological Fertility Project at Almazov National Medical Research Center. Based on the data of Russian and international literature, as well as existing guidelines and recommendations on reproductive health, a single algorithm for selecting patients has been developed, considering the expected gonadal toxicity for the use of the OTC in prepubertal girls. The developed algorithm allows identifying patients of prepubertal age, requiring the use of new possibilities of reproductive technologies. In a long-term date, we are planning to evaluate the effectiveness of the orthotopic reimplantation technique of the cryopreserved ovarian tissue in restoring the reproductive function. A multidisciplinary team of specialists and the possibilities of the Federal Center facilitate implementing the Oncofertility Program in routine practice for girls and young women, receiving gonadotoxic treatment.

AB - In children with cancer, the issues related to the quality of life are becoming increasingly important together with the improvement of survival rates. This creates an entirely new challenge–minimizing the toxicity of the antitumor therapy without reducing its effectiveness. One of the specific side effects of the antitumor therapy is gonadotoxicity, which negatively affects both the somatic and mental state of the survivors. Since ovarian stimulation is ineffective in prepubertal patients, ovarian tissue cryopreservation (OTC) remains the most promising option to preserve fertility. The primary goal of this publication is to emphasize the importance of the reproductive health problem in girls with oncological diseases, with a description of the current data of international literature on the prospects of OTC in order to preserve fertility. Another goal is to present a multidisciplinary strategy for the management of prepubertal age patients with the oncological disease within the framework of the Oncological Fertility Project at Almazov National Medical Research Center. Based on the data of Russian and international literature, as well as existing guidelines and recommendations on reproductive health, a single algorithm for selecting patients has been developed, considering the expected gonadal toxicity for the use of the OTC in prepubertal girls. The developed algorithm allows identifying patients of prepubertal age, requiring the use of new possibilities of reproductive technologies. In a long-term date, we are planning to evaluate the effectiveness of the orthotopic reimplantation technique of the cryopreserved ovarian tissue in restoring the reproductive function. A multidisciplinary team of specialists and the possibilities of the Federal Center facilitate implementing the Oncofertility Program in routine practice for girls and young women, receiving gonadotoxic treatment.

KW - Chemotherapy

KW - children

KW - cryopreservation of ovarian tissue

KW - fertility

KW - infertility

KW - oncology

KW - reproduction

KW - Humans

KW - Fertility Preservation

KW - Russia

KW - Ovary

KW - Neoplasms/therapy

KW - Cryopreservation

KW - Quality of Life

KW - Female

KW - Child

KW - FERTILITY PRESERVATION

KW - INSUFFICIENCY

KW - PUBERTY

KW - TRANSPLANTATION

KW - MENOPAUSE

KW - PREGNANCY

KW - WOMEN

KW - YOUNG

KW - AUTOGRAFT

KW - SURVIVORS

UR - http://www.scopus.com/inward/record.url?scp=85073992180&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/6548157c-e5ae-3420-bace-fc816c50aa57/

U2 - 10.1080/14767058.2019.1666364

DO - 10.1080/14767058.2019.1666364

M3 - Review article

C2 - 31500478

AN - SCOPUS:85073992180

VL - 34

SP - 2391

EP - 2398

JO - Journal of Maternal-Fetal and Neonatal Medicine

JF - Journal of Maternal-Fetal and Neonatal Medicine

SN - 1476-7058

IS - 14

ER -