Research output: Contribution to journal › Review article › peer-review
Ovarian tissue cryopreservation in prepubertal patients with oncological diseases : multidisciplinary approach and outcomes. / Dinikina, Yulia; Belogurova, Margarita; Zaritskey, Andrey; Govorov, Igor; Tsibizova, Valentina; Gamzatova, Zaynab; Pervunina, Tatyana; Komlichenko, Eduard.
In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 34, No. 14, 18.07.2021, p. 2391-2398.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Ovarian tissue cryopreservation in prepubertal patients with oncological diseases
T2 - multidisciplinary approach and outcomes
AU - Dinikina, Yulia
AU - Belogurova, Margarita
AU - Zaritskey, Andrey
AU - Govorov, Igor
AU - Tsibizova, Valentina
AU - Gamzatova, Zaynab
AU - Pervunina, Tatyana
AU - Komlichenko, Eduard
N1 - Publisher Copyright: © 2019 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021/7/18
Y1 - 2021/7/18
N2 - In children with cancer, the issues related to the quality of life are becoming increasingly important together with the improvement of survival rates. This creates an entirely new challenge–minimizing the toxicity of the antitumor therapy without reducing its effectiveness. One of the specific side effects of the antitumor therapy is gonadotoxicity, which negatively affects both the somatic and mental state of the survivors. Since ovarian stimulation is ineffective in prepubertal patients, ovarian tissue cryopreservation (OTC) remains the most promising option to preserve fertility. The primary goal of this publication is to emphasize the importance of the reproductive health problem in girls with oncological diseases, with a description of the current data of international literature on the prospects of OTC in order to preserve fertility. Another goal is to present a multidisciplinary strategy for the management of prepubertal age patients with the oncological disease within the framework of the Oncological Fertility Project at Almazov National Medical Research Center. Based on the data of Russian and international literature, as well as existing guidelines and recommendations on reproductive health, a single algorithm for selecting patients has been developed, considering the expected gonadal toxicity for the use of the OTC in prepubertal girls. The developed algorithm allows identifying patients of prepubertal age, requiring the use of new possibilities of reproductive technologies. In a long-term date, we are planning to evaluate the effectiveness of the orthotopic reimplantation technique of the cryopreserved ovarian tissue in restoring the reproductive function. A multidisciplinary team of specialists and the possibilities of the Federal Center facilitate implementing the Oncofertility Program in routine practice for girls and young women, receiving gonadotoxic treatment.
AB - In children with cancer, the issues related to the quality of life are becoming increasingly important together with the improvement of survival rates. This creates an entirely new challenge–minimizing the toxicity of the antitumor therapy without reducing its effectiveness. One of the specific side effects of the antitumor therapy is gonadotoxicity, which negatively affects both the somatic and mental state of the survivors. Since ovarian stimulation is ineffective in prepubertal patients, ovarian tissue cryopreservation (OTC) remains the most promising option to preserve fertility. The primary goal of this publication is to emphasize the importance of the reproductive health problem in girls with oncological diseases, with a description of the current data of international literature on the prospects of OTC in order to preserve fertility. Another goal is to present a multidisciplinary strategy for the management of prepubertal age patients with the oncological disease within the framework of the Oncological Fertility Project at Almazov National Medical Research Center. Based on the data of Russian and international literature, as well as existing guidelines and recommendations on reproductive health, a single algorithm for selecting patients has been developed, considering the expected gonadal toxicity for the use of the OTC in prepubertal girls. The developed algorithm allows identifying patients of prepubertal age, requiring the use of new possibilities of reproductive technologies. In a long-term date, we are planning to evaluate the effectiveness of the orthotopic reimplantation technique of the cryopreserved ovarian tissue in restoring the reproductive function. A multidisciplinary team of specialists and the possibilities of the Federal Center facilitate implementing the Oncofertility Program in routine practice for girls and young women, receiving gonadotoxic treatment.
KW - Chemotherapy
KW - children
KW - cryopreservation of ovarian tissue
KW - fertility
KW - infertility
KW - oncology
KW - reproduction
KW - Humans
KW - Fertility Preservation
KW - Russia
KW - Ovary
KW - Neoplasms/therapy
KW - Cryopreservation
KW - Quality of Life
KW - Female
KW - Child
KW - FERTILITY PRESERVATION
KW - INSUFFICIENCY
KW - PUBERTY
KW - TRANSPLANTATION
KW - MENOPAUSE
KW - PREGNANCY
KW - WOMEN
KW - YOUNG
KW - AUTOGRAFT
KW - SURVIVORS
UR - http://www.scopus.com/inward/record.url?scp=85073992180&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/6548157c-e5ae-3420-bace-fc816c50aa57/
U2 - 10.1080/14767058.2019.1666364
DO - 10.1080/14767058.2019.1666364
M3 - Review article
C2 - 31500478
AN - SCOPUS:85073992180
VL - 34
SP - 2391
EP - 2398
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
SN - 1476-7058
IS - 14
ER -
ID: 87783582