Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
Opioid Neurobiology, Neurogenetics and Neuropharmacology in Zebrafish. / Bao, Wandong; Volgin, Andrey D.; Alpyshov, Erik T.; Friend, Ashton; Strekalova, Tatyana V.; de Abreu, Murilo S; Collins, Christopher; Amstislavskaya, Tamara G.; Демин, Константин Андреевич; Kalueff, Allan V.
в: Neuroscience, Том 404, 2019, стр. 218-232.Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
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TY - JOUR
T1 - Opioid Neurobiology, Neurogenetics and Neuropharmacology in Zebrafish
AU - Bao, Wandong
AU - Volgin, Andrey D.
AU - Alpyshov, Erik T.
AU - Friend, Ashton
AU - Strekalova, Tatyana V.
AU - de Abreu, Murilo S
AU - Collins, Christopher
AU - Amstislavskaya, Tamara G.
AU - Демин, Константин Андреевич
AU - Kalueff, Allan V.
PY - 2019
Y1 - 2019
N2 - Despite the high prevalence of medicinal use and abuse of opioids, their neurobiology and mechanisms of action are not fully understood. Experimental (animal) models are critical for improving our understanding of opioid effects in vivo. As zebrafish (Danio rerio) are increasingly utilized as a powerful model organism in neuroscience research, mounting evidence suggests these fish as a useful tool to study opioid neurobiology. Here, we discuss the zebrafish opioid system with specific focus on opioid gene expression, existing genetic models, as well as its pharmacological and developmental regulation. As many human brain diseases involve pain and aberrant reward, we also summarize zebrafish models relevant to opioid regulation of pain and addiction, including evidence of functional interplay between the opioid system and central dopaminergic and other neurotransmitter mechanisms. Additionally, we critically evaluate the limitations of zebrafish models for translational opioid research and emphasize their developing utility for improving our understanding of evolutionarily conserved mechanisms of pain-related, addictive, affective and other behaviors, as well as for fostering opioid-related drug discovery.
AB - Despite the high prevalence of medicinal use and abuse of opioids, their neurobiology and mechanisms of action are not fully understood. Experimental (animal) models are critical for improving our understanding of opioid effects in vivo. As zebrafish (Danio rerio) are increasingly utilized as a powerful model organism in neuroscience research, mounting evidence suggests these fish as a useful tool to study opioid neurobiology. Here, we discuss the zebrafish opioid system with specific focus on opioid gene expression, existing genetic models, as well as its pharmacological and developmental regulation. As many human brain diseases involve pain and aberrant reward, we also summarize zebrafish models relevant to opioid regulation of pain and addiction, including evidence of functional interplay between the opioid system and central dopaminergic and other neurotransmitter mechanisms. Additionally, we critically evaluate the limitations of zebrafish models for translational opioid research and emphasize their developing utility for improving our understanding of evolutionarily conserved mechanisms of pain-related, addictive, affective and other behaviors, as well as for fostering opioid-related drug discovery.
KW - behavior
KW - genetic models
KW - opioids
KW - pain
KW - reward system
KW - zebrafish
UR - http://www.scopus.com/inward/record.url?scp=85062214908&partnerID=8YFLogxK
U2 - 10.1016/j.neuroscience.2019.01.045
DO - 10.1016/j.neuroscience.2019.01.045
M3 - Review article
VL - 404
SP - 218
EP - 232
JO - Neuroscience
JF - Neuroscience
SN - 0306-4522
ER -
ID: 39072252