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Opioid Neurobiology, Neurogenetics and Neuropharmacology in Zebrafish. / Bao, Wandong; Volgin, Andrey D.; Alpyshov, Erik T.; Friend, Ashton; Strekalova, Tatyana V.; de Abreu, Murilo S; Collins, Christopher; Amstislavskaya, Tamara G.; Демин, Константин Андреевич; Kalueff, Allan V.

In: Neuroscience, Vol. 404, 2019, p. 218-232.

Research output: Contribution to journalReview articlepeer-review

Harvard

Bao, W, Volgin, AD, Alpyshov, ET, Friend, A, Strekalova, TV, de Abreu, MS, Collins, C, Amstislavskaya, TG, Демин, КА & Kalueff, AV 2019, 'Opioid Neurobiology, Neurogenetics and Neuropharmacology in Zebrafish', Neuroscience, vol. 404, pp. 218-232. https://doi.org/10.1016/j.neuroscience.2019.01.045

APA

Bao, W., Volgin, A. D., Alpyshov, E. T., Friend, A., Strekalova, T. V., de Abreu, M. S., Collins, C., Amstislavskaya, T. G., Демин, К. А., & Kalueff, A. V. (2019). Opioid Neurobiology, Neurogenetics and Neuropharmacology in Zebrafish. Neuroscience, 404, 218-232. https://doi.org/10.1016/j.neuroscience.2019.01.045

Vancouver

Bao W, Volgin AD, Alpyshov ET, Friend A, Strekalova TV, de Abreu MS et al. Opioid Neurobiology, Neurogenetics and Neuropharmacology in Zebrafish. Neuroscience. 2019;404:218-232. https://doi.org/10.1016/j.neuroscience.2019.01.045

Author

Bao, Wandong ; Volgin, Andrey D. ; Alpyshov, Erik T. ; Friend, Ashton ; Strekalova, Tatyana V. ; de Abreu, Murilo S ; Collins, Christopher ; Amstislavskaya, Tamara G. ; Демин, Константин Андреевич ; Kalueff, Allan V. / Opioid Neurobiology, Neurogenetics and Neuropharmacology in Zebrafish. In: Neuroscience. 2019 ; Vol. 404. pp. 218-232.

BibTeX

@article{5c37daa8e6ca4e408db2ac6d2aaf2bf9,
title = "Opioid Neurobiology, Neurogenetics and Neuropharmacology in Zebrafish",
abstract = "Despite the high prevalence of medicinal use and abuse of opioids, their neurobiology and mechanisms of action are not fully understood. Experimental (animal) models are critical for improving our understanding of opioid effects in vivo. As zebrafish (Danio rerio) are increasingly utilized as a powerful model organism in neuroscience research, mounting evidence suggests these fish as a useful tool to study opioid neurobiology. Here, we discuss the zebrafish opioid system with specific focus on opioid gene expression, existing genetic models, as well as its pharmacological and developmental regulation. As many human brain diseases involve pain and aberrant reward, we also summarize zebrafish models relevant to opioid regulation of pain and addiction, including evidence of functional interplay between the opioid system and central dopaminergic and other neurotransmitter mechanisms. Additionally, we critically evaluate the limitations of zebrafish models for translational opioid research and emphasize their developing utility for improving our understanding of evolutionarily conserved mechanisms of pain-related, addictive, affective and other behaviors, as well as for fostering opioid-related drug discovery.",
keywords = "behavior, genetic models, opioids, pain, reward system, zebrafish",
author = "Wandong Bao and Volgin, {Andrey D.} and Alpyshov, {Erik T.} and Ashton Friend and Strekalova, {Tatyana V.} and {de Abreu}, {Murilo S} and Christopher Collins and Amstislavskaya, {Tamara G.} and Демин, {Константин Андреевич} and Kalueff, {Allan V.}",
year = "2019",
doi = "10.1016/j.neuroscience.2019.01.045",
language = "English",
volume = "404",
pages = "218--232",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Opioid Neurobiology, Neurogenetics and Neuropharmacology in Zebrafish

AU - Bao, Wandong

AU - Volgin, Andrey D.

AU - Alpyshov, Erik T.

AU - Friend, Ashton

AU - Strekalova, Tatyana V.

AU - de Abreu, Murilo S

AU - Collins, Christopher

AU - Amstislavskaya, Tamara G.

AU - Демин, Константин Андреевич

AU - Kalueff, Allan V.

PY - 2019

Y1 - 2019

N2 - Despite the high prevalence of medicinal use and abuse of opioids, their neurobiology and mechanisms of action are not fully understood. Experimental (animal) models are critical for improving our understanding of opioid effects in vivo. As zebrafish (Danio rerio) are increasingly utilized as a powerful model organism in neuroscience research, mounting evidence suggests these fish as a useful tool to study opioid neurobiology. Here, we discuss the zebrafish opioid system with specific focus on opioid gene expression, existing genetic models, as well as its pharmacological and developmental regulation. As many human brain diseases involve pain and aberrant reward, we also summarize zebrafish models relevant to opioid regulation of pain and addiction, including evidence of functional interplay between the opioid system and central dopaminergic and other neurotransmitter mechanisms. Additionally, we critically evaluate the limitations of zebrafish models for translational opioid research and emphasize their developing utility for improving our understanding of evolutionarily conserved mechanisms of pain-related, addictive, affective and other behaviors, as well as for fostering opioid-related drug discovery.

AB - Despite the high prevalence of medicinal use and abuse of opioids, their neurobiology and mechanisms of action are not fully understood. Experimental (animal) models are critical for improving our understanding of opioid effects in vivo. As zebrafish (Danio rerio) are increasingly utilized as a powerful model organism in neuroscience research, mounting evidence suggests these fish as a useful tool to study opioid neurobiology. Here, we discuss the zebrafish opioid system with specific focus on opioid gene expression, existing genetic models, as well as its pharmacological and developmental regulation. As many human brain diseases involve pain and aberrant reward, we also summarize zebrafish models relevant to opioid regulation of pain and addiction, including evidence of functional interplay between the opioid system and central dopaminergic and other neurotransmitter mechanisms. Additionally, we critically evaluate the limitations of zebrafish models for translational opioid research and emphasize their developing utility for improving our understanding of evolutionarily conserved mechanisms of pain-related, addictive, affective and other behaviors, as well as for fostering opioid-related drug discovery.

KW - behavior

KW - genetic models

KW - opioids

KW - pain

KW - reward system

KW - zebrafish

UR - http://www.scopus.com/inward/record.url?scp=85062214908&partnerID=8YFLogxK

U2 - 10.1016/j.neuroscience.2019.01.045

DO - 10.1016/j.neuroscience.2019.01.045

M3 - Review article

VL - 404

SP - 218

EP - 232

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

ER -

ID: 39072252