Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
Natural compounds as inhibitors of thioredoxin reductase (TrxR1). / Chupakhin, E. G.; Krasavin, M. Yu.
в: Russian Chemical Bulletin, Том 71, № 3, 01.03.2022, стр. 443-448.Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
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TY - JOUR
T1 - Natural compounds as inhibitors of thioredoxin reductase (TrxR1)
AU - Chupakhin, E. G.
AU - Krasavin, M. Yu
N1 - Chupakhin, E.G., Krasavin, M.Y. Natural compounds as inhibitors of thioredoxin reductase (TrxR1). Russ Chem Bull 71, 443–448 (2022). https://doi.org/10.1007/s11172-022-3431-4
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Recent achievements in the area of studying biological activity of new natural compounds toward thioredoxin reductase 1 (TrxR1) are considered. The most important chemotypes of the compounds exhibiting activity toward TrxR1 were revealed. The pharmacophoric environment of the electron-deficient olefin group that possesses a chemical potential for covalent inhibiting to TrxR1 was examined.
AB - Recent achievements in the area of studying biological activity of new natural compounds toward thioredoxin reductase 1 (TrxR1) are considered. The most important chemotypes of the compounds exhibiting activity toward TrxR1 were revealed. The pharmacophoric environment of the electron-deficient olefin group that possesses a chemical potential for covalent inhibiting to TrxR1 was examined.
KW - natural compounds
KW - oxidative stress
KW - target for anticancer drugs
KW - thioredoxin reductase
UR - http://www.scopus.com/inward/record.url?scp=85128837358&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/418a3b7b-353e-349c-af57-fe9cbb784848/
U2 - 10.1007/s11172-022-3431-4
DO - 10.1007/s11172-022-3431-4
M3 - Review article
AN - SCOPUS:85128837358
VL - 71
SP - 443
EP - 448
JO - Russian Chemical Bulletin
JF - Russian Chemical Bulletin
SN - 1066-5285
IS - 3
ER -
ID: 94860734