TY - GEN

T1 - MRI contrast agent based on maghemite nanoparticles

AU - Osmolowskaya, Olga

AU - Kozlova, Margarita

AU - Korzhikov, Victor

AU - Dobrodumov, Anatolyi

AU - Murin, Igor

AU - Osmolowsky, Mikhail

PY - 2013

Y1 - 2013

N2 - In this study the maghemite nanoparticles have been obtained via application of original approach within hydrothermal synthesis method. The morphology parameters have been determined by a number of methods including XRD, TEM and specific surface area estimation (the BET model). The magnetic properties of the nanoparticles have been measured using VSM that confirmed superparamagnetic behavior of the powder at 300 K with the blocking temperature value near 80 K. The aqueous suspensions of the obtained nanoparticles have been studied by DLS method; their temporal stability has been evaluated. The analysis of relaxation times in model system has shown their applicability as a MRI contrast agent. In order to turn the obtained nanoparticles into dosage form two approaches have been studied: covering their surface with model protein and encapsulation of the nanoparticles into a polymer nanocontainer.

AB - In this study the maghemite nanoparticles have been obtained via application of original approach within hydrothermal synthesis method. The morphology parameters have been determined by a number of methods including XRD, TEM and specific surface area estimation (the BET model). The magnetic properties of the nanoparticles have been measured using VSM that confirmed superparamagnetic behavior of the powder at 300 K with the blocking temperature value near 80 K. The aqueous suspensions of the obtained nanoparticles have been studied by DLS method; their temporal stability has been evaluated. The analysis of relaxation times in model system has shown their applicability as a MRI contrast agent. In order to turn the obtained nanoparticles into dosage form two approaches have been studied: covering their surface with model protein and encapsulation of the nanoparticles into a polymer nanocontainer.

KW - Colloid

KW - Contrast agent

KW - Iron oxide

KW - Magnetic resonance imaging

KW - Superparamagnetism

UR - http://www.scopus.com/inward/record.url?scp=84929414040&partnerID=8YFLogxK

M3 - Conference contribution

SN - 9788087294475

T3 - NANOCON 2013 - Conference Proceedings, 5th International Conference

SP - 532

EP - 537

BT - NANOCON 2013 - Conference Proceedings, 5th International Conference

PB - TANGER, Ltd.

T2 - 5th International Conference NANOCON 2013

Y2 - 16 October 2013 through 18 October 2013

ER -