TY - JOUR

T1 - Molecular mechanisms of antitumor effect of natural antimicrobial peptides

AU - Balandin, S. V.

AU - Emelianova, A. A.

AU - Kalashnikova, M. B.

AU - Kokryakov, V. N.

AU - Shamova, O. V.

AU - Ovchinnikova, T. V.

PY - 2016/11

Y1 - 2016/11

N2 - In spite of all the advances in cancer treatment made in recent years, one of the main problems in this field that remains extremely urgent is the development of drug resistance to the chemotherapeutic agents currently in use due to clonal microevolution of tumor tissue. Numerous publications devoted to the study of cationic antimicrobial peptides (AMPs) as molecular factors of the innate immune system suggest that these compounds possess significant therapeutic potential and can be considered as candidates for the role of not only antimicrobial, but also next-generation anticancer drugs. AMPs are characterized by a variety of mechanisms of cytotoxic action that can lead to either necrosis or apoptosis of the target cells. These effects are based on the selective interaction with the membranes of tumor cells, which have a number of similarities, in structural and physiological aspects, with the microbial membranes. AMPs were found to be able to inhibit tumor growth by interrupting the formation of its vascular network. The antitumor effect of AMPs may also be enhanced by the modulation of host immune system, as previously observed for their antimicrobial effects. The described properties of AMPs give hope for the development of new drugs that will be able to overcome the resistance of tumor cells.

AB - In spite of all the advances in cancer treatment made in recent years, one of the main problems in this field that remains extremely urgent is the development of drug resistance to the chemotherapeutic agents currently in use due to clonal microevolution of tumor tissue. Numerous publications devoted to the study of cationic antimicrobial peptides (AMPs) as molecular factors of the innate immune system suggest that these compounds possess significant therapeutic potential and can be considered as candidates for the role of not only antimicrobial, but also next-generation anticancer drugs. AMPs are characterized by a variety of mechanisms of cytotoxic action that can lead to either necrosis or apoptosis of the target cells. These effects are based on the selective interaction with the membranes of tumor cells, which have a number of similarities, in structural and physiological aspects, with the microbial membranes. AMPs were found to be able to inhibit tumor growth by interrupting the formation of its vascular network. The antitumor effect of AMPs may also be enhanced by the modulation of host immune system, as previously observed for their antimicrobial effects. The described properties of AMPs give hope for the development of new drugs that will be able to overcome the resistance of tumor cells.

KW - antimicrobial peptides

KW - host defense peptides

KW - innate immunity

KW - peptide antibiotics

KW - anticancer drugs

KW - apoptosis

KW - necrosis

KW - HOST-DEFENSE PEPTIDES

KW - SQUAMOUS-CELL CARCINOMA

KW - RAS-TRANSFORMED CELLS

KW - KILLS CANCER-CELLS

KW - TUMOR-CELLS

KW - IN-VITRO

KW - BOVINE LACTOFERRICIN

KW - LYTIC PEPTIDES

KW - LEUKEMIA-CELLS

KW - INNATE IMMUNITY

U2 - 10.1134/S1068162016060029

DO - 10.1134/S1068162016060029

M3 - Обзорная статья

VL - 42

SP - 575

EP - 589

JO - Russian Journal of Bioorganic Chemistry

JF - Russian Journal of Bioorganic Chemistry

SN - 1068-1620

IS - 6

ER -