Research output: Contribution to journal › Review article › peer-review
Molecular mechanisms of antitumor effect of natural antimicrobial peptides. / Balandin, S. V.; Emelianova, A. A.; Kalashnikova, M. B.; Kokryakov, V. N.; Shamova, O. V.; Ovchinnikova, T. V.
In: Russian Journal of Bioorganic Chemistry, Vol. 42, No. 6, 11.2016, p. 575-589.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Molecular mechanisms of antitumor effect of natural antimicrobial peptides
AU - Balandin, S. V.
AU - Emelianova, A. A.
AU - Kalashnikova, M. B.
AU - Kokryakov, V. N.
AU - Shamova, O. V.
AU - Ovchinnikova, T. V.
PY - 2016/11
Y1 - 2016/11
N2 - In spite of all the advances in cancer treatment made in recent years, one of the main problems in this field that remains extremely urgent is the development of drug resistance to the chemotherapeutic agents currently in use due to clonal microevolution of tumor tissue. Numerous publications devoted to the study of cationic antimicrobial peptides (AMPs) as molecular factors of the innate immune system suggest that these compounds possess significant therapeutic potential and can be considered as candidates for the role of not only antimicrobial, but also next-generation anticancer drugs. AMPs are characterized by a variety of mechanisms of cytotoxic action that can lead to either necrosis or apoptosis of the target cells. These effects are based on the selective interaction with the membranes of tumor cells, which have a number of similarities, in structural and physiological aspects, with the microbial membranes. AMPs were found to be able to inhibit tumor growth by interrupting the formation of its vascular network. The antitumor effect of AMPs may also be enhanced by the modulation of host immune system, as previously observed for their antimicrobial effects. The described properties of AMPs give hope for the development of new drugs that will be able to overcome the resistance of tumor cells.
AB - In spite of all the advances in cancer treatment made in recent years, one of the main problems in this field that remains extremely urgent is the development of drug resistance to the chemotherapeutic agents currently in use due to clonal microevolution of tumor tissue. Numerous publications devoted to the study of cationic antimicrobial peptides (AMPs) as molecular factors of the innate immune system suggest that these compounds possess significant therapeutic potential and can be considered as candidates for the role of not only antimicrobial, but also next-generation anticancer drugs. AMPs are characterized by a variety of mechanisms of cytotoxic action that can lead to either necrosis or apoptosis of the target cells. These effects are based on the selective interaction with the membranes of tumor cells, which have a number of similarities, in structural and physiological aspects, with the microbial membranes. AMPs were found to be able to inhibit tumor growth by interrupting the formation of its vascular network. The antitumor effect of AMPs may also be enhanced by the modulation of host immune system, as previously observed for their antimicrobial effects. The described properties of AMPs give hope for the development of new drugs that will be able to overcome the resistance of tumor cells.
KW - antimicrobial peptides
KW - host defense peptides
KW - innate immunity
KW - peptide antibiotics
KW - anticancer drugs
KW - apoptosis
KW - necrosis
KW - HOST-DEFENSE PEPTIDES
KW - SQUAMOUS-CELL CARCINOMA
KW - RAS-TRANSFORMED CELLS
KW - KILLS CANCER-CELLS
KW - TUMOR-CELLS
KW - IN-VITRO
KW - BOVINE LACTOFERRICIN
KW - LYTIC PEPTIDES
KW - LEUKEMIA-CELLS
KW - INNATE IMMUNITY
U2 - 10.1134/S1068162016060029
DO - 10.1134/S1068162016060029
M3 - Обзорная статья
VL - 42
SP - 575
EP - 589
JO - Russian Journal of Bioorganic Chemistry
JF - Russian Journal of Bioorganic Chemistry
SN - 1068-1620
IS - 6
ER -
ID: 9366668