Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Modification of PCL Scaffolds by Reactive Magnetron Sputtering : A Possibility for Modulating Macrophage Responses. / Stankevich, Ksenia S.; Kudryavtseva, Valeriya L.; Bolbasov, Evgeny N.; Shesterikov, Evgeny V.; Larionova, Irina V.; Shapovalova, Yelena G.; Domracheva, Liubov V.; Volokhova, Apollinariya A.; Kurzina, Irina A.; Zhukov, Yuri M.; Malashicheva, Anna B.; Kzhyshkowska, Julia G.; Tverdokhlebov, Sergei I.
в: ACS Biomaterials Science and Engineering, Том 6, № 7, 13.07.2020, стр. 3967-3974.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Modification of PCL Scaffolds by Reactive Magnetron Sputtering
T2 - A Possibility for Modulating Macrophage Responses
AU - Stankevich, Ksenia S.
AU - Kudryavtseva, Valeriya L.
AU - Bolbasov, Evgeny N.
AU - Shesterikov, Evgeny V.
AU - Larionova, Irina V.
AU - Shapovalova, Yelena G.
AU - Domracheva, Liubov V.
AU - Volokhova, Apollinariya A.
AU - Kurzina, Irina A.
AU - Zhukov, Yuri M.
AU - Malashicheva, Anna B.
AU - Kzhyshkowska, Julia G.
AU - Tverdokhlebov, Sergei I.
N1 - Funding Information: This work was financially supported by the Tomsk Polytechnic University Competitiveness Enhancement Program and Russian State Project “Science” (FSWW-2020-0011). Publisher Copyright: Copyright © 2020 American Chemical Society. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/7/13
Y1 - 2020/7/13
N2 - Direct current (DC) reactive magnetron sputtering is as an efficient method for enhancing the biocompatibility of poly(ϵ-caprolactone) (PCL) scaffolds. However, the PCL chemical bonding state, the composition of the deposited coating, and their interaction with immune cells remain unknown. Herein, we demonstrated that the DC reactive magnetron sputtering of the titanium target in a nitrogen atmosphere leads to the formation of nitrogen-containing moieties and the titanium dioxide coating on the scaffold surface. We have provided the possible mechanism of PCL fragmentation and coating formation supported by XPS results and DFT calculations. Our preliminary biological studies suggest that DC reactive magnetron sputtering of the titanium target could be an effective tool to control macrophage functional responses toward PCL scaffolds as it allows to inhibit respiratory burst while retaining cell viability and scavenging activity.
AB - Direct current (DC) reactive magnetron sputtering is as an efficient method for enhancing the biocompatibility of poly(ϵ-caprolactone) (PCL) scaffolds. However, the PCL chemical bonding state, the composition of the deposited coating, and their interaction with immune cells remain unknown. Herein, we demonstrated that the DC reactive magnetron sputtering of the titanium target in a nitrogen atmosphere leads to the formation of nitrogen-containing moieties and the titanium dioxide coating on the scaffold surface. We have provided the possible mechanism of PCL fragmentation and coating formation supported by XPS results and DFT calculations. Our preliminary biological studies suggest that DC reactive magnetron sputtering of the titanium target could be an effective tool to control macrophage functional responses toward PCL scaffolds as it allows to inhibit respiratory burst while retaining cell viability and scavenging activity.
KW - DFT
KW - immune response
KW - macrophage
KW - magnetron sputtering
KW - poly(ϵ-caprolactone) scaffolds
KW - THIN-FILMS
KW - INFLAMMATORY RESPONSES
KW - DEPOSITION
KW - SURFACE MODIFICATION
KW - TITANIUM
KW - IN-VITRO
KW - poly(epsilon-caprolactone) scaffolds
KW - ELECTROSPUN FIBROUS SCAFFOLDS
KW - BIOMEDICAL APPLICATIONS
KW - FABRICATION
KW - POLARIZATION
UR - http://www.scopus.com/inward/record.url?scp=85090347854&partnerID=8YFLogxK
U2 - 10.1021/acsbiomaterials.0c00440
DO - 10.1021/acsbiomaterials.0c00440
M3 - Article
AN - SCOPUS:85090347854
VL - 6
SP - 3967
EP - 3974
JO - ACS Biomaterials Science and Engineering
JF - ACS Biomaterials Science and Engineering
SN - 2373-9878
IS - 7
ER -
ID: 71709351