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Modification of PCL Scaffolds by Reactive Magnetron Sputtering : A Possibility for Modulating Macrophage Responses. / Stankevich, Ksenia S.; Kudryavtseva, Valeriya L.; Bolbasov, Evgeny N.; Shesterikov, Evgeny V.; Larionova, Irina V.; Shapovalova, Yelena G.; Domracheva, Liubov V.; Volokhova, Apollinariya A.; Kurzina, Irina A.; Zhukov, Yuri M.; Malashicheva, Anna B.; Kzhyshkowska, Julia G.; Tverdokhlebov, Sergei I.

In: ACS Biomaterials Science and Engineering, Vol. 6, No. 7, 13.07.2020, p. 3967-3974.

Research output: Contribution to journal › Article › peer-review

Harvard

Stankevich, KS, Kudryavtseva, VL, Bolbasov, EN, Shesterikov, EV, Larionova, IV, Shapovalova, YG, Domracheva, LV, Volokhova, AA, Kurzina, IA, Zhukov, YM, Malashicheva, AB, Kzhyshkowska, JG & Tverdokhlebov, SI 2020, 'Modification of PCL Scaffolds by Reactive Magnetron Sputtering: A Possibility for Modulating Macrophage Responses', ACS Biomaterials Science and Engineering, vol. 6, no. 7, pp. 3967-3974. https://doi.org/10.1021/acsbiomaterials.0c00440

APA

Stankevich, K. S., Kudryavtseva, V. L., Bolbasov, E. N., Shesterikov, E. V., Larionova, I. V., Shapovalova, Y. G., Domracheva, L. V., Volokhova, A. A., Kurzina, I. A., Zhukov, Y. M., Malashicheva, A. B., Kzhyshkowska, J. G., & Tverdokhlebov, S. I. (2020). Modification of PCL Scaffolds by Reactive Magnetron Sputtering: A Possibility for Modulating Macrophage Responses. ACS Biomaterials Science and Engineering, 6(7), 3967-3974. https://doi.org/10.1021/acsbiomaterials.0c00440

Vancouver

Stankevich KS, Kudryavtseva VL, Bolbasov EN, Shesterikov EV, Larionova IV, Shapovalova YG et al. Modification of PCL Scaffolds by Reactive Magnetron Sputtering: A Possibility for Modulating Macrophage Responses. ACS Biomaterials Science and Engineering. 2020 Jul 13;6(7):3967-3974. https://doi.org/10.1021/acsbiomaterials.0c00440

Author

Stankevich, Ksenia S. ; Kudryavtseva, Valeriya L. ; Bolbasov, Evgeny N. ; Shesterikov, Evgeny V. ; Larionova, Irina V. ; Shapovalova, Yelena G. ; Domracheva, Liubov V. ; Volokhova, Apollinariya A. ; Kurzina, Irina A. ; Zhukov, Yuri M. ; Malashicheva, Anna B. ; Kzhyshkowska, Julia G. ; Tverdokhlebov, Sergei I. / Modification of PCL Scaffolds by Reactive Magnetron Sputtering : A Possibility for Modulating Macrophage Responses. In: ACS Biomaterials Science and Engineering. 2020 ; Vol. 6, No. 7. pp. 3967-3974.

BibTeX

@article{30dd3febf2c14e73babfd321577ec045,
title = "Modification of PCL Scaffolds by Reactive Magnetron Sputtering: A Possibility for Modulating Macrophage Responses",
abstract = "Direct current (DC) reactive magnetron sputtering is as an efficient method for enhancing the biocompatibility of poly(ϵ-caprolactone) (PCL) scaffolds. However, the PCL chemical bonding state, the composition of the deposited coating, and their interaction with immune cells remain unknown. Herein, we demonstrated that the DC reactive magnetron sputtering of the titanium target in a nitrogen atmosphere leads to the formation of nitrogen-containing moieties and the titanium dioxide coating on the scaffold surface. We have provided the possible mechanism of PCL fragmentation and coating formation supported by XPS results and DFT calculations. Our preliminary biological studies suggest that DC reactive magnetron sputtering of the titanium target could be an effective tool to control macrophage functional responses toward PCL scaffolds as it allows to inhibit respiratory burst while retaining cell viability and scavenging activity. ",
keywords = "DFT, immune response, macrophage, magnetron sputtering, poly(ϵ-caprolactone) scaffolds, THIN-FILMS, INFLAMMATORY RESPONSES, DEPOSITION, SURFACE MODIFICATION, TITANIUM, IN-VITRO, poly(epsilon-caprolactone) scaffolds, ELECTROSPUN FIBROUS SCAFFOLDS, BIOMEDICAL APPLICATIONS, FABRICATION, POLARIZATION",
author = "Stankevich, {Ksenia S.} and Kudryavtseva, {Valeriya L.} and Bolbasov, {Evgeny N.} and Shesterikov, {Evgeny V.} and Larionova, {Irina V.} and Shapovalova, {Yelena G.} and Domracheva, {Liubov V.} and Volokhova, {Apollinariya A.} and Kurzina, {Irina A.} and Zhukov, {Yuri M.} and Malashicheva, {Anna B.} and Kzhyshkowska, {Julia G.} and Tverdokhlebov, {Sergei I.}",
note = "Funding Information: This work was financially supported by the Tomsk Polytechnic University Competitiveness Enhancement Program and Russian State Project “Science” (FSWW-2020-0011). Publisher Copyright: Copyright {\textcopyright} 2020 American Chemical Society. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = jul,
day = "13",
doi = "10.1021/acsbiomaterials.0c00440",
language = "English",
volume = "6",
pages = "3967--3974",
journal = "ACS Biomaterials Science and Engineering",
issn = "2373-9878",
publisher = "American Chemical Society",
number = "7",

}

RIS

TY - JOUR

T1 - Modification of PCL Scaffolds by Reactive Magnetron Sputtering

T2 - A Possibility for Modulating Macrophage Responses

AU - Stankevich, Ksenia S.

AU - Kudryavtseva, Valeriya L.

AU - Bolbasov, Evgeny N.

AU - Shesterikov, Evgeny V.

AU - Larionova, Irina V.

AU - Shapovalova, Yelena G.

AU - Domracheva, Liubov V.

AU - Volokhova, Apollinariya A.

AU - Kurzina, Irina A.

AU - Zhukov, Yuri M.

AU - Malashicheva, Anna B.

AU - Kzhyshkowska, Julia G.

AU - Tverdokhlebov, Sergei I.

N1 - Funding Information: This work was financially supported by the Tomsk Polytechnic University Competitiveness Enhancement Program and Russian State Project “Science” (FSWW-2020-0011). Publisher Copyright: Copyright © 2020 American Chemical Society. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/7/13

Y1 - 2020/7/13

N2 - Direct current (DC) reactive magnetron sputtering is as an efficient method for enhancing the biocompatibility of poly(ϵ-caprolactone) (PCL) scaffolds. However, the PCL chemical bonding state, the composition of the deposited coating, and their interaction with immune cells remain unknown. Herein, we demonstrated that the DC reactive magnetron sputtering of the titanium target in a nitrogen atmosphere leads to the formation of nitrogen-containing moieties and the titanium dioxide coating on the scaffold surface. We have provided the possible mechanism of PCL fragmentation and coating formation supported by XPS results and DFT calculations. Our preliminary biological studies suggest that DC reactive magnetron sputtering of the titanium target could be an effective tool to control macrophage functional responses toward PCL scaffolds as it allows to inhibit respiratory burst while retaining cell viability and scavenging activity.

AB - Direct current (DC) reactive magnetron sputtering is as an efficient method for enhancing the biocompatibility of poly(ϵ-caprolactone) (PCL) scaffolds. However, the PCL chemical bonding state, the composition of the deposited coating, and their interaction with immune cells remain unknown. Herein, we demonstrated that the DC reactive magnetron sputtering of the titanium target in a nitrogen atmosphere leads to the formation of nitrogen-containing moieties and the titanium dioxide coating on the scaffold surface. We have provided the possible mechanism of PCL fragmentation and coating formation supported by XPS results and DFT calculations. Our preliminary biological studies suggest that DC reactive magnetron sputtering of the titanium target could be an effective tool to control macrophage functional responses toward PCL scaffolds as it allows to inhibit respiratory burst while retaining cell viability and scavenging activity.

KW - DFT

KW - immune response

KW - macrophage

KW - magnetron sputtering

KW - poly(ϵ-caprolactone) scaffolds

KW - THIN-FILMS

KW - INFLAMMATORY RESPONSES

KW - DEPOSITION

KW - SURFACE MODIFICATION

KW - TITANIUM

KW - IN-VITRO

KW - poly(epsilon-caprolactone) scaffolds

KW - ELECTROSPUN FIBROUS SCAFFOLDS

KW - BIOMEDICAL APPLICATIONS

KW - FABRICATION

KW - POLARIZATION

UR - http://www.scopus.com/inward/record.url?scp=85090347854&partnerID=8YFLogxK

U2 - 10.1021/acsbiomaterials.0c00440

DO - 10.1021/acsbiomaterials.0c00440

M3 - Article

AN - SCOPUS:85090347854

VL - 6

SP - 3967

EP - 3974

JO - ACS Biomaterials Science and Engineering

JF - ACS Biomaterials Science and Engineering

SN - 2373-9878

IS - 7

ER -

ID: 71709351