TY - JOUR

T1 - Modeling of schizophrenia with Levodopa+Carbidopa

AU - Kutcher, E. O.

AU - Egorov, A. Yu

AU - Chernikova, N. A.

AU - Filatova, E. V.

PY - 2013/12/27

Y1 - 2013/12/27

N2 - Experimental modeling of mental disorders on animal helps both to reveal mechanisms of the appearance of pathology and to direct the ways of effective methods of its treatment. The goal of the present work was to create a new model of schizophrenia by oral Levodopa+Carbidopa (LC) administration. Introduction of LC to rats was found to induces a significant decrease of emotional reactions, hypersensitivity to sound stimuli, a reduction of exploratory activity, stereotype behavior, and motor hyperactivity in occasional rats. It is concluded that the LC administration to rats may be used as an alternative dopaminergic model of schizophrenia on animals.

AB - Experimental modeling of mental disorders on animal helps both to reveal mechanisms of the appearance of pathology and to direct the ways of effective methods of its treatment. The goal of the present work was to create a new model of schizophrenia by oral Levodopa+Carbidopa (LC) administration. Introduction of LC to rats was found to induces a significant decrease of emotional reactions, hypersensitivity to sound stimuli, a reduction of exploratory activity, stereotype behavior, and motor hyperactivity in occasional rats. It is concluded that the LC administration to rats may be used as an alternative dopaminergic model of schizophrenia on animals.

KW - dopamine

KW - Levodopa+Carbidopa (LC)

KW - modeling of schizophrenia on animals

UR - http://www.scopus.com/inward/record.url?scp=84890889163&partnerID=8YFLogxK

U2 - 10.1134/S002209301305006X

DO - 10.1134/S002209301305006X

M3 - Article

AN - SCOPUS:84890889163

VL - 49

SP - 503

EP - 508

JO - Journal of Evolutionary Biochemistry and Physiology

JF - Journal of Evolutionary Biochemistry and Physiology

SN - 0022-0930

IS - 5

ER -