Research output: Contribution to journal › Article › peer-review
Modeling of schizophrenia with Levodopa+Carbidopa. / Kutcher, E. O.; Egorov, A. Yu; Chernikova, N. A.; Filatova, E. V.
In: Journal of Evolutionary Biochemistry and Physiology, Vol. 49, No. 5, 27.12.2013, p. 503-508.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Modeling of schizophrenia with Levodopa+Carbidopa
AU - Kutcher, E. O.
AU - Egorov, A. Yu
AU - Chernikova, N. A.
AU - Filatova, E. V.
PY - 2013/12/27
Y1 - 2013/12/27
N2 - Experimental modeling of mental disorders on animal helps both to reveal mechanisms of the appearance of pathology and to direct the ways of effective methods of its treatment. The goal of the present work was to create a new model of schizophrenia by oral Levodopa+Carbidopa (LC) administration. Introduction of LC to rats was found to induces a significant decrease of emotional reactions, hypersensitivity to sound stimuli, a reduction of exploratory activity, stereotype behavior, and motor hyperactivity in occasional rats. It is concluded that the LC administration to rats may be used as an alternative dopaminergic model of schizophrenia on animals.
AB - Experimental modeling of mental disorders on animal helps both to reveal mechanisms of the appearance of pathology and to direct the ways of effective methods of its treatment. The goal of the present work was to create a new model of schizophrenia by oral Levodopa+Carbidopa (LC) administration. Introduction of LC to rats was found to induces a significant decrease of emotional reactions, hypersensitivity to sound stimuli, a reduction of exploratory activity, stereotype behavior, and motor hyperactivity in occasional rats. It is concluded that the LC administration to rats may be used as an alternative dopaminergic model of schizophrenia on animals.
KW - dopamine
KW - Levodopa+Carbidopa (LC)
KW - modeling of schizophrenia on animals
UR - http://www.scopus.com/inward/record.url?scp=84890889163&partnerID=8YFLogxK
U2 - 10.1134/S002209301305006X
DO - 10.1134/S002209301305006X
M3 - Article
AN - SCOPUS:84890889163
VL - 49
SP - 503
EP - 508
JO - Journal of Evolutionary Biochemistry and Physiology
JF - Journal of Evolutionary Biochemistry and Physiology
SN - 0022-0930
IS - 5
ER -
ID: 50489679