Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Model of cooperative interaction of TMPyP4 porphyrine with DNA quadruplex. / Kudrev, A. G.
в: Russian Journal of General Chemistry, Том 86, № 6, 01.06.2016, стр. 1353-1363.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Model of cooperative interaction of TMPyP4 porphyrine with DNA quadruplex
AU - Kudrev, A. G.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Intrinsic binding constants of the TMPyP4 porphyrin with G-quadruplex of DNA (ckit2) have been calculated; they can be applied as reference for quantitative evaluation of the possibility of such structures participation in biochemical processes. The conclusion about existence of two different sites of the TMPyP4 binding to ckit2 binding made earlier on the basis of the stepwise complex formation model has been revised using the model of mutual influence (cooperativity) of the ligands bound to the oligonucleotide. The model has been verified using principal component analysis and factor analysis methods. The ckit2 biomolecule can be considered as an oligonucleotide with equivalent mutually affecting binding sites.
AB - Intrinsic binding constants of the TMPyP4 porphyrin with G-quadruplex of DNA (ckit2) have been calculated; they can be applied as reference for quantitative evaluation of the possibility of such structures participation in biochemical processes. The conclusion about existence of two different sites of the TMPyP4 binding to ckit2 binding made earlier on the basis of the stepwise complex formation model has been revised using the model of mutual influence (cooperativity) of the ligands bound to the oligonucleotide. The model has been verified using principal component analysis and factor analysis methods. The ckit2 biomolecule can be considered as an oligonucleotide with equivalent mutually affecting binding sites.
KW - cooperativity
KW - DNA
KW - G-quadruplex
KW - TMPyP4
UR - http://www.scopus.com/inward/record.url?scp=84982732861&partnerID=8YFLogxK
U2 - 10.1134/S1070363216060219
DO - 10.1134/S1070363216060219
M3 - Article
AN - SCOPUS:84982732861
VL - 86
SP - 1353
EP - 1363
JO - Russian Journal of General Chemistry
JF - Russian Journal of General Chemistry
SN - 1070-3632
IS - 6
ER -
ID: 38693920