Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Methotrexate-loaded metal-organic frameworks on the basis of γ-cyclodextrin : Design, characterization, in vitro and in vivo investigation. / Kritskiy, Iliya; Volkova, Tatyana; Sapozhnikova, Tatyana; Mazur, Anton; Tolstoy, Peter; Terekhova, Irina.
в: Materials Science and Engineering C, Том 111, 110774, 06.2020.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Methotrexate-loaded metal-organic frameworks on the basis of γ-cyclodextrin
T2 - Design, characterization, in vitro and in vivo investigation
AU - Kritskiy, Iliya
AU - Volkova, Tatyana
AU - Sapozhnikova, Tatyana
AU - Mazur, Anton
AU - Tolstoy, Peter
AU - Terekhova, Irina
PY - 2020/6
Y1 - 2020/6
N2 - In this work, metal-organic frameworks on the basis of γ-cyclodextrin (γCD-MOF) were proposed as carriers for methotrexate (MTX) which is widely used as chemotherapy agent and immune system suppressant. The synthesized γCD-MOF was loaded with MTX by impregnation and co-crystallization. The obtained composites were characterized using powder X-ray diffraction, N2 adsorption/desorption, FTIR spectroscopy, solid-state 13C MAS CP/TOSS NMR and scanning electron microscopy. Pharmaceutically relevant properties of MTX alone and loaded in γCD-MOF were investigated in vitro and in vivo. The faster dissolution of MTX incorporated in γCD-MOF was demonstrated in blank buffers and biorelevant media (FaSSGF, FaSSIF) simulating the gastrointestinal fluids. Inclusion complex formation of MTX with γ-CD enhances the drug dissolution rate and, at the same time, slightly decreases the drug permeability through the lipophilic membrane. The in vivo experiments showed the improved pharmacokinetic parameters of MTX loaded in γCD-MOF.
AB - In this work, metal-organic frameworks on the basis of γ-cyclodextrin (γCD-MOF) were proposed as carriers for methotrexate (MTX) which is widely used as chemotherapy agent and immune system suppressant. The synthesized γCD-MOF was loaded with MTX by impregnation and co-crystallization. The obtained composites were characterized using powder X-ray diffraction, N2 adsorption/desorption, FTIR spectroscopy, solid-state 13C MAS CP/TOSS NMR and scanning electron microscopy. Pharmaceutically relevant properties of MTX alone and loaded in γCD-MOF were investigated in vitro and in vivo. The faster dissolution of MTX incorporated in γCD-MOF was demonstrated in blank buffers and biorelevant media (FaSSGF, FaSSIF) simulating the gastrointestinal fluids. Inclusion complex formation of MTX with γ-CD enhances the drug dissolution rate and, at the same time, slightly decreases the drug permeability through the lipophilic membrane. The in vivo experiments showed the improved pharmacokinetic parameters of MTX loaded in γCD-MOF.
KW - Bioavailability
KW - Biorelevant media
KW - Dissolution
KW - Metal-organic frameworks
KW - Methotrexate
KW - Permeability
KW - PERMEABILITY
KW - DRUG-DELIVERY
KW - ENCAPSULATION
KW - ADSORPTION
KW - BIOAVAILABILITY
KW - SOLUBILITY
KW - CD-MOF
KW - NANOPARTICLES
KW - PERMEAPAD(TM)
KW - DISSOLUTION MEDIA
UR - http://www.scopus.com/inward/record.url?scp=85080974892&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/6e19f8f5-c717-38f9-8c9d-02bb8155a8b0/
U2 - 10.1016/j.msec.2020.110774
DO - 10.1016/j.msec.2020.110774
M3 - Article
C2 - 32279736
AN - SCOPUS:85080974892
VL - 111
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
SN - 0928-4931
M1 - 110774
ER -
ID: 53584732