Methotrexate-loaded metal-organic frameworks on the basis of γ-cyclodextrin

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Methotrexate-loaded metal-organic frameworks on the basis of γ-cyclodextrin : Design, characterization, in vitro and in vivo investigation. / Kritskiy, Iliya; Volkova, Tatyana; Sapozhnikova, Tatyana; Mazur, Anton; Tolstoy, Peter; Terekhova, Irina.

In: Materials Science and Engineering C, Vol. 111, 110774, 06.2020.

Research output: Contribution to journal › Article › peer-review

Author

Kritskiy, Iliya ; Volkova, Tatyana ; Sapozhnikova, Tatyana ; Mazur, Anton ; Tolstoy, Peter ; Terekhova, Irina. / Methotrexate-loaded metal-organic frameworks on the basis of γ-cyclodextrin : Design, characterization, in vitro and in vivo investigation. In: Materials Science and Engineering C. 2020 ; Vol. 111.

BibTeX

@article{015d16161c9e43f19c47372c9771034c,

title = "Methotrexate-loaded metal-organic frameworks on the basis of γ-cyclodextrin: Design, characterization, in vitro and in vivo investigation",

abstract = "In this work, metal-organic frameworks on the basis of γ-cyclodextrin (γCD-MOF) were proposed as carriers for methotrexate (MTX) which is widely used as chemotherapy agent and immune system suppressant. The synthesized γCD-MOF was loaded with MTX by impregnation and co-crystallization. The obtained composites were characterized using powder X-ray diffraction, N2 adsorption/desorption, FTIR spectroscopy, solid-state 13C MAS CP/TOSS NMR and scanning electron microscopy. Pharmaceutically relevant properties of MTX alone and loaded in γCD-MOF were investigated in vitro and in vivo. The faster dissolution of MTX incorporated in γCD-MOF was demonstrated in blank buffers and biorelevant media (FaSSGF, FaSSIF) simulating the gastrointestinal fluids. Inclusion complex formation of MTX with γ-CD enhances the drug dissolution rate and, at the same time, slightly decreases the drug permeability through the lipophilic membrane. The in vivo experiments showed the improved pharmacokinetic parameters of MTX loaded in γCD-MOF.",

keywords = "Bioavailability, Biorelevant media, Dissolution, Metal-organic frameworks, Methotrexate, Permeability, PERMEABILITY, DRUG-DELIVERY, ENCAPSULATION, ADSORPTION, BIOAVAILABILITY, SOLUBILITY, CD-MOF, NANOPARTICLES, PERMEAPAD(TM), DISSOLUTION MEDIA",

author = "Iliya Kritskiy and Tatyana Volkova and Tatyana Sapozhnikova and Anton Mazur and Peter Tolstoy and Irina Terekhova",

year = "2020",

month = jun,

doi = "10.1016/j.msec.2020.110774",

language = "English",

volume = "111",

journal = "Materials Science and Engineering C",

issn = "0928-4931",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Methotrexate-loaded metal-organic frameworks on the basis of γ-cyclodextrin

T2 - Design, characterization, in vitro and in vivo investigation

AU - Kritskiy, Iliya

AU - Volkova, Tatyana

AU - Sapozhnikova, Tatyana

AU - Mazur, Anton

AU - Tolstoy, Peter

AU - Terekhova, Irina

PY - 2020/6

Y1 - 2020/6

N2 - In this work, metal-organic frameworks on the basis of γ-cyclodextrin (γCD-MOF) were proposed as carriers for methotrexate (MTX) which is widely used as chemotherapy agent and immune system suppressant. The synthesized γCD-MOF was loaded with MTX by impregnation and co-crystallization. The obtained composites were characterized using powder X-ray diffraction, N2 adsorption/desorption, FTIR spectroscopy, solid-state 13C MAS CP/TOSS NMR and scanning electron microscopy. Pharmaceutically relevant properties of MTX alone and loaded in γCD-MOF were investigated in vitro and in vivo. The faster dissolution of MTX incorporated in γCD-MOF was demonstrated in blank buffers and biorelevant media (FaSSGF, FaSSIF) simulating the gastrointestinal fluids. Inclusion complex formation of MTX with γ-CD enhances the drug dissolution rate and, at the same time, slightly decreases the drug permeability through the lipophilic membrane. The in vivo experiments showed the improved pharmacokinetic parameters of MTX loaded in γCD-MOF.

AB - In this work, metal-organic frameworks on the basis of γ-cyclodextrin (γCD-MOF) were proposed as carriers for methotrexate (MTX) which is widely used as chemotherapy agent and immune system suppressant. The synthesized γCD-MOF was loaded with MTX by impregnation and co-crystallization. The obtained composites were characterized using powder X-ray diffraction, N2 adsorption/desorption, FTIR spectroscopy, solid-state 13C MAS CP/TOSS NMR and scanning electron microscopy. Pharmaceutically relevant properties of MTX alone and loaded in γCD-MOF were investigated in vitro and in vivo. The faster dissolution of MTX incorporated in γCD-MOF was demonstrated in blank buffers and biorelevant media (FaSSGF, FaSSIF) simulating the gastrointestinal fluids. Inclusion complex formation of MTX with γ-CD enhances the drug dissolution rate and, at the same time, slightly decreases the drug permeability through the lipophilic membrane. The in vivo experiments showed the improved pharmacokinetic parameters of MTX loaded in γCD-MOF.

KW - Bioavailability

KW - Biorelevant media

KW - Dissolution

KW - Metal-organic frameworks

KW - Methotrexate

KW - Permeability

KW - PERMEABILITY

KW - DRUG-DELIVERY

KW - ENCAPSULATION

KW - ADSORPTION

KW - BIOAVAILABILITY

KW - SOLUBILITY

KW - CD-MOF

KW - NANOPARTICLES

KW - PERMEAPAD(TM)

KW - DISSOLUTION MEDIA

UR - http://www.scopus.com/inward/record.url?scp=85080974892&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/6e19f8f5-c717-38f9-8c9d-02bb8155a8b0/

U2 - 10.1016/j.msec.2020.110774

DO - 10.1016/j.msec.2020.110774

M3 - Article

C2 - 32279736

AN - SCOPUS:85080974892

VL - 111

JO - Materials Science and Engineering C

JF - Materials Science and Engineering C

SN - 0928-4931

M1 - 110774

ER -

ID: 53584732