Mechanism of Activation of Enteric Nociceptive Neurons via Interaction of TLR4 and TRPV1 Receptors

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Mechanism of Activation of Enteric Nociceptive Neurons via Interaction of TLR4 and TRPV1 Receptors. / Filippova, L. V.; Fedorova, A. V.; Nozdrachev, A. D.

в: Doklady Biological Sciences, Том 479, № 1, 01.03.2018, стр. 44-46.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

BibTeX

@article{5395ab6380e34cd2adcb33e934a40b44,

title = "Mechanism of Activation of Enteric Nociceptive Neurons via Interaction of TLR4 and TRPV1 Receptors",

abstract = "Evidence obtained by immunohistochemical double labeling and confocal laser scanning microscopy suggests that capsaicin, a ligand of the TRPV1 nociceptive vanilloid receptor, increases the number of TLR4-positive neurons in the rat colon myenteric plexus. In colitis caused by trinitrobenzene sulfonate, an increase in TRPV1 expression was more significant in both plexuses. Specific inhibitor of the TLR4 (C34) pattern-recognition receptor reduces TRPV1 expression in enteric neurons of both intact rats and rats with induced acute colitis. Thus, stimulation of nociceptive neurons by means of direct activation of their receptors of innate immunity (TLR4) is one of the possible mechanisms underlying the visceral pain in bacterial invasion and inflammatory bowel diseases.",

author = "Filippova, {L. V.} and Fedorova, {A. V.} and Nozdrachev, {A. D.}",

year = "2018",

month = mar,

day = "1",

doi = "10.1134/S0012496618020023",

language = "English",

volume = "479",

pages = "44--46",

journal = "Doklady Biological Sciences",

issn = "0012-4966",

publisher = "МАИК {"}Наука/Интерпериодика{"}",

number = "1",

}

RIS

TY - JOUR

T1 - Mechanism of Activation of Enteric Nociceptive Neurons via Interaction of TLR4 and TRPV1 Receptors

AU - Filippova, L. V.

AU - Fedorova, A. V.

AU - Nozdrachev, A. D.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Evidence obtained by immunohistochemical double labeling and confocal laser scanning microscopy suggests that capsaicin, a ligand of the TRPV1 nociceptive vanilloid receptor, increases the number of TLR4-positive neurons in the rat colon myenteric plexus. In colitis caused by trinitrobenzene sulfonate, an increase in TRPV1 expression was more significant in both plexuses. Specific inhibitor of the TLR4 (C34) pattern-recognition receptor reduces TRPV1 expression in enteric neurons of both intact rats and rats with induced acute colitis. Thus, stimulation of nociceptive neurons by means of direct activation of their receptors of innate immunity (TLR4) is one of the possible mechanisms underlying the visceral pain in bacterial invasion and inflammatory bowel diseases.

AB - Evidence obtained by immunohistochemical double labeling and confocal laser scanning microscopy suggests that capsaicin, a ligand of the TRPV1 nociceptive vanilloid receptor, increases the number of TLR4-positive neurons in the rat colon myenteric plexus. In colitis caused by trinitrobenzene sulfonate, an increase in TRPV1 expression was more significant in both plexuses. Specific inhibitor of the TLR4 (C34) pattern-recognition receptor reduces TRPV1 expression in enteric neurons of both intact rats and rats with induced acute colitis. Thus, stimulation of nociceptive neurons by means of direct activation of their receptors of innate immunity (TLR4) is one of the possible mechanisms underlying the visceral pain in bacterial invasion and inflammatory bowel diseases.

UR - http://www.scopus.com/inward/record.url?scp=85047487302&partnerID=8YFLogxK

U2 - 10.1134/S0012496618020023

DO - 10.1134/S0012496618020023

M3 - Article

C2 - 29790024

AN - SCOPUS:85047487302

VL - 479

SP - 44

EP - 46

JO - Doklady Biological Sciences

JF - Doklady Biological Sciences

SN - 0012-4966

IS - 1

ER -

ID: 37012978