DOI

Evidence obtained by immunohistochemical double labeling and confocal laser scanning microscopy suggests that capsaicin, a ligand of the TRPV1 nociceptive vanilloid receptor, increases the number of TLR4-positive neurons in the rat colon myenteric plexus. In colitis caused by trinitrobenzene sulfonate, an increase in TRPV1 expression was more significant in both plexuses. Specific inhibitor of the TLR4 (C34) pattern-recognition receptor reduces TRPV1 expression in enteric neurons of both intact rats and rats with induced acute colitis. Thus, stimulation of nociceptive neurons by means of direct activation of their receptors of innate immunity (TLR4) is one of the possible mechanisms underlying the visceral pain in bacterial invasion and inflammatory bowel diseases.

Язык оригиналаанглийский
Страницы (с-по)44-46
Число страниц3
ЖурналDoklady Biological Sciences
Том479
Номер выпуска1
DOI
СостояниеОпубликовано - 1 мар 2018

    Предметные области Scopus

  • Биохимия, генетика и молекулярная биология (все)
  • Иммунология и микробиология (все)
  • Земледелие и биологические науки (все)

ID: 37012978