Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Markers of cellular senescence. Telomere shortening as a marker of cellular senescence. / Bernadotte, Alexandra; Mikhelson, Victor M.; Spivak, Irina M.
в: Aging, Том 8, № 1, 2016, стр. 3-11.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
}
TY - JOUR
T1 - Markers of cellular senescence. Telomere shortening as a marker of cellular senescence
AU - Bernadotte, Alexandra
AU - Mikhelson, Victor M.
AU - Spivak, Irina M.
PY - 2016
Y1 - 2016
N2 - The cellular senescence definition comes to the fact of cells irreversible proliferation disability. Besides the cell cycle arrest, senescent cells go through some morphological, biochemical, and functional changes which are the signs of cellular senescence. The senescent cells (including replicative senescence and stress-induced premature senescence) of all the tissues look alike. They are metabolically active and possess the set of characteristics in vitro and in vivo, which are known as biomarkers of aging and cellular senescence. Among biomarkers of cellular senescence telomere shortening is a rather elegant frequently used biomarker. Validity of telomere shortening as a marker for cellular senescence is based on theoretical and experimental data.
AB - The cellular senescence definition comes to the fact of cells irreversible proliferation disability. Besides the cell cycle arrest, senescent cells go through some morphological, biochemical, and functional changes which are the signs of cellular senescence. The senescent cells (including replicative senescence and stress-induced premature senescence) of all the tissues look alike. They are metabolically active and possess the set of characteristics in vitro and in vivo, which are known as biomarkers of aging and cellular senescence. Among biomarkers of cellular senescence telomere shortening is a rather elegant frequently used biomarker. Validity of telomere shortening as a marker for cellular senescence is based on theoretical and experimental data.
KW - Aging
KW - Biomarkers
KW - Cellular senescence
KW - Replicative senescence
KW - Telomere
KW - Telomere theory
UR - http://www.scopus.com/inward/record.url?scp=84986567947&partnerID=8YFLogxK
U2 - 10.18632/aging.100871
DO - 10.18632/aging.100871
M3 - Article
C2 - 26805432
AN - SCOPUS:84986567947
VL - 8
SP - 3
EP - 11
JO - Aging
JF - Aging
SN - 1945-4589
IS - 1
ER -
ID: 97786252