TY - JOUR

T1 - Impact of prionization of the Sup35 protein [PSI+] on the frequency of genetic changes, accounted in the alpha-test in yeast Saccharomyces cerevisiae

AU - Andreychuk, Yu V.

AU - Shiryaeva, A. A.

AU - Zhuk, A. S.

AU - Stepchenkova, E. I.

AU - Inge-Vechtomov, S. G.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Amyloidogenesis in nerve tissues cause human diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, and the illness of Louis Gehrig, characterized by specific neurodegenerative symptoms. The frequency of nerve cells with an abnormal number of chromosomes is increased in patients with Alzheimer’s disease. However, the direct impact of prions on the genome stability has not been sufficiently investigated. In our work, we studied the impact of the [PSI+] prions on the stability of the S. cerevisiae genome using the alpha-test system.

AB - Amyloidogenesis in nerve tissues cause human diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, and the illness of Louis Gehrig, characterized by specific neurodegenerative symptoms. The frequency of nerve cells with an abnormal number of chromosomes is increased in patients with Alzheimer’s disease. However, the direct impact of prions on the genome stability has not been sufficiently investigated. In our work, we studied the impact of the [PSI+] prions on the stability of the S. cerevisiae genome using the alpha-test system.

KW - genome stability

KW - mutagenesis

KW - mutational test systems

KW - prion

UR - http://www.scopus.com/inward/record.url?scp=85016007995&partnerID=8YFLogxK

U2 - 10.1134/S2079059717020022

DO - 10.1134/S2079059717020022

M3 - Article

AN - SCOPUS:85016007995

VL - 7

SP - 172

EP - 174

JO - Russian Journal of Genetics: Applied Research

JF - Russian Journal of Genetics: Applied Research

SN - 2079-0597

IS - 2

ER -