Amyloidogenesis in nerve tissues cause human diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, and the illness of Louis Gehrig, characterized by specific neurodegenerative symptoms. The frequency of nerve cells with an abnormal number of chromosomes is increased in patients with Alzheimer’s disease. However, the direct impact of prions on the genome stability has not been sufficiently investigated. In our work, we studied the impact of the [PSI+] prions on the stability of the S. cerevisiae genome using the alpha-test system.