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Hyaluronan/colistin polyelectrolyte complexes : Promising antiinfective drug delivery systems. / Dubashynskaya, Natallia V.; Raik, Sergei V.; Dubrovskii, Yaroslav A.; Shcherbakova, Elena S.; Demyanova, Elena V.; Shasherina, Anna Y.; Anufrikov, Yuri A.; Poshina, Daria N.; Dobrodumov, Anatoliy V.; Skorik, Yury A.

в: International Journal of Biological Macromolecules, Том 187, 30.09.2021, стр. 157-165.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

Harvard

Dubashynskaya, NV, Raik, SV, Dubrovskii, YA, Shcherbakova, ES, Demyanova, EV, Shasherina, AY, Anufrikov, YA, Poshina, DN, Dobrodumov, AV & Skorik, YA 2021, 'Hyaluronan/colistin polyelectrolyte complexes: Promising antiinfective drug delivery systems', International Journal of Biological Macromolecules, Том. 187, стр. 157-165. https://doi.org/10.1016/j.ijbiomac.2021.07.114

APA

Dubashynskaya, N. V., Raik, S. V., Dubrovskii, Y. A., Shcherbakova, E. S., Demyanova, E. V., Shasherina, A. Y., Anufrikov, Y. A., Poshina, D. N., Dobrodumov, A. V., & Skorik, Y. A. (2021). Hyaluronan/colistin polyelectrolyte complexes: Promising antiinfective drug delivery systems. International Journal of Biological Macromolecules, 187, 157-165. https://doi.org/10.1016/j.ijbiomac.2021.07.114

Vancouver

Dubashynskaya NV, Raik SV, Dubrovskii YA, Shcherbakova ES, Demyanova EV, Shasherina AY и пр. Hyaluronan/colistin polyelectrolyte complexes: Promising antiinfective drug delivery systems. International Journal of Biological Macromolecules. 2021 Сент. 30;187:157-165. https://doi.org/10.1016/j.ijbiomac.2021.07.114

Author

Dubashynskaya, Natallia V. ; Raik, Sergei V. ; Dubrovskii, Yaroslav A. ; Shcherbakova, Elena S. ; Demyanova, Elena V. ; Shasherina, Anna Y. ; Anufrikov, Yuri A. ; Poshina, Daria N. ; Dobrodumov, Anatoliy V. ; Skorik, Yury A. / Hyaluronan/colistin polyelectrolyte complexes : Promising antiinfective drug delivery systems. в: International Journal of Biological Macromolecules. 2021 ; Том 187. стр. 157-165.

BibTeX

@article{806f35ec3d8b4405add492582183d8ac,
title = "Hyaluronan/colistin polyelectrolyte complexes: Promising antiinfective drug delivery systems",
abstract = "Nanotechnology-based modification of known antimicrobial agents is a rational and straightforward way to improve their safety and effectiveness. The aim of this study was to develop colistin (CT)-loaded polymeric carriers based on hyaluronic acid (HA) for potential application as antimicrobial agents against multi-resistant gram-negative microorganisms (including ESKAPE pathogens). CT-containing particles were obtained via a polyelectrolyte interaction between protonated CT amino groups and HA carboxyl groups (the CT-HA complex formation constant [logKCT-HA] was about 5.0). The resulting polyelectrolyte complexes had a size of 210–250 nm and a negative charge (ζ-potential −19 mV), with encapsulation and loading efficiencies of 100% and 20%, respectively. The developed CT delivery systems were characterized by modified release (45% and 85% of CT released in 15 and 60 min, respectively) compared to pure CT (100% CT released in 15 min). In vitro tests showed that the encapsulation of CT in polymer particles did not reduce its pharmacological activity; the minimum inhibitory concentrations of both encapsulated CT and pure CT were 1 μg/mL (against Pseudomonas aeruginosa).",
keywords = "Colistin, Hyaluronic acid, drug delivery system, Colistin, Drug delivery system, Hyaluronic acid, ANTIBIOTICS, INFECTIONS, POLYMYXINS, NANOCARRIERS, HYALURONIC-ACID, FUNCTIONALIZATION, NANOPARTICLES, PEPTIDES, COLISTIN, RESISTANCE",
author = "Dubashynskaya, {Natallia V.} and Raik, {Sergei V.} and Dubrovskii, {Yaroslav A.} and Shcherbakova, {Elena S.} and Demyanova, {Elena V.} and Shasherina, {Anna Y.} and Anufrikov, {Yuri A.} and Poshina, {Daria N.} and Dobrodumov, {Anatoliy V.} and Skorik, {Yury A.}",
note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",
year = "2021",
month = sep,
day = "30",
doi = "10.1016/j.ijbiomac.2021.07.114",
language = "English",
volume = "187",
pages = "157--165",
journal = "International Journal of Biological Macromolecules",
issn = "0141-8130",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Hyaluronan/colistin polyelectrolyte complexes

T2 - Promising antiinfective drug delivery systems

AU - Dubashynskaya, Natallia V.

AU - Raik, Sergei V.

AU - Dubrovskii, Yaroslav A.

AU - Shcherbakova, Elena S.

AU - Demyanova, Elena V.

AU - Shasherina, Anna Y.

AU - Anufrikov, Yuri A.

AU - Poshina, Daria N.

AU - Dobrodumov, Anatoliy V.

AU - Skorik, Yury A.

N1 - Publisher Copyright: © 2021 Elsevier B.V.

PY - 2021/9/30

Y1 - 2021/9/30

N2 - Nanotechnology-based modification of known antimicrobial agents is a rational and straightforward way to improve their safety and effectiveness. The aim of this study was to develop colistin (CT)-loaded polymeric carriers based on hyaluronic acid (HA) for potential application as antimicrobial agents against multi-resistant gram-negative microorganisms (including ESKAPE pathogens). CT-containing particles were obtained via a polyelectrolyte interaction between protonated CT amino groups and HA carboxyl groups (the CT-HA complex formation constant [logKCT-HA] was about 5.0). The resulting polyelectrolyte complexes had a size of 210–250 nm and a negative charge (ζ-potential −19 mV), with encapsulation and loading efficiencies of 100% and 20%, respectively. The developed CT delivery systems were characterized by modified release (45% and 85% of CT released in 15 and 60 min, respectively) compared to pure CT (100% CT released in 15 min). In vitro tests showed that the encapsulation of CT in polymer particles did not reduce its pharmacological activity; the minimum inhibitory concentrations of both encapsulated CT and pure CT were 1 μg/mL (against Pseudomonas aeruginosa).

AB - Nanotechnology-based modification of known antimicrobial agents is a rational and straightforward way to improve their safety and effectiveness. The aim of this study was to develop colistin (CT)-loaded polymeric carriers based on hyaluronic acid (HA) for potential application as antimicrobial agents against multi-resistant gram-negative microorganisms (including ESKAPE pathogens). CT-containing particles were obtained via a polyelectrolyte interaction between protonated CT amino groups and HA carboxyl groups (the CT-HA complex formation constant [logKCT-HA] was about 5.0). The resulting polyelectrolyte complexes had a size of 210–250 nm and a negative charge (ζ-potential −19 mV), with encapsulation and loading efficiencies of 100% and 20%, respectively. The developed CT delivery systems were characterized by modified release (45% and 85% of CT released in 15 and 60 min, respectively) compared to pure CT (100% CT released in 15 min). In vitro tests showed that the encapsulation of CT in polymer particles did not reduce its pharmacological activity; the minimum inhibitory concentrations of both encapsulated CT and pure CT were 1 μg/mL (against Pseudomonas aeruginosa).

KW - Colistin, Hyaluronic acid, drug delivery system

KW - Colistin

KW - Drug delivery system

KW - Hyaluronic acid

KW - ANTIBIOTICS

KW - INFECTIONS

KW - POLYMYXINS

KW - NANOCARRIERS

KW - HYALURONIC-ACID

KW - FUNCTIONALIZATION

KW - NANOPARTICLES

KW - PEPTIDES

KW - COLISTIN

KW - RESISTANCE

UR - https://proxy.library.spbu.ru:2068/science/article/pii/S0141813021015646?via%3Dihub

UR - http://www.scopus.com/inward/record.url?scp=85111059423&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/e1f01331-55c9-39f3-92d0-37be93d8e938/

U2 - 10.1016/j.ijbiomac.2021.07.114

DO - 10.1016/j.ijbiomac.2021.07.114

M3 - Article

VL - 187

SP - 157

EP - 165

JO - International Journal of Biological Macromolecules

JF - International Journal of Biological Macromolecules

SN - 0141-8130

ER -

ID: 87285952