Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Genomic legacy of the African cheetah, Acinonyx jubatus. / Dobrynin, P.; Liu, S.; Tamazian, G.; Xiong, Z.; Yurchenko, A.A.; Krasheninnikova, K.; Kliver, S.; Schmidt-Küntzel, A.; Koepfli, K.-P.; Johnson, W.; Kuderna, L.F.K.; Garc a-Pérez, R.; Manuel, M.; Godinez, R.; Komissarov, A.; Makunin, A.; Brukhin, V.; Qiu, W.; Zhou, L.; Li, F.; Yi, J.; Driscoll, C.; Antunes, A.; Oleksyk, T.K.; Eizirik, E.; Perelman, P.; Roelke, M.; Wildt, D.; Diekhans, M.; Marques-Bonet, T.; Marker, L.; Bhak, J.; Wang, J.; Zhang, G.; O'Brien, S.J.
в: Genome Biology, Том 16, № 1, 2015, стр. 277.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Genomic legacy of the African cheetah, Acinonyx jubatus
AU - Dobrynin, P.
AU - Liu, S.
AU - Tamazian, G.
AU - Xiong, Z.
AU - Yurchenko, A.A.
AU - Krasheninnikova, K.
AU - Kliver, S.
AU - Schmidt-Küntzel, A.
AU - Koepfli, K.-P.
AU - Johnson, W.
AU - Kuderna, L.F.K.
AU - Garc a-Pérez, R.
AU - Manuel, M.
AU - Godinez, R.
AU - Komissarov, A.
AU - Makunin, A.
AU - Brukhin, V.
AU - Qiu, W.
AU - Zhou, L.
AU - Li, F.
AU - Yi, J.
AU - Driscoll, C.
AU - Antunes, A.
AU - Oleksyk, T.K.
AU - Eizirik, E.
AU - Perelman, P.
AU - Roelke, M.
AU - Wildt, D.
AU - Diekhans, M.
AU - Marques-Bonet, T.
AU - Marker, L.
AU - Bhak, J.
AU - Wang, J.
AU - Zhang, G.
AU - O'Brien, S.J.
PY - 2015
Y1 - 2015
N2 - Background: Patterns of genetic and genomic variance are informative in inferring population history for human, model species and endangered populations.Results: Here the genome sequence of wild-born African cheetahs reveals extreme genomic depletion in SNV incidence, SNV density, SNVs of coding genes, MHC class I and II genes, and mitochondrial DNA SNVs. Cheetah genomes are on average 95 % homozygous compared to the genomes of the outbred domestic cat (24.08 % homozygous), Virunga Mountain Gorilla (78.12 %), inbred Abyssinian cat (62.63 %), Tasmanian devil, domestic dog and other mammalian species. Demographic estimators impute two ancestral population bottlenecks: one >100,000 years ago coincident with cheetah migrations out of the Americas and into Eurasia and Africa, and a second 11,084-12,589 years ago in Africa coincident with late Pleistocene large mammal extinctions. MHC class I gene loss and dramatic reduction in functional diversity of MHC genes would explain why cheetahs ablate skin graft rejection
AB - Background: Patterns of genetic and genomic variance are informative in inferring population history for human, model species and endangered populations.Results: Here the genome sequence of wild-born African cheetahs reveals extreme genomic depletion in SNV incidence, SNV density, SNVs of coding genes, MHC class I and II genes, and mitochondrial DNA SNVs. Cheetah genomes are on average 95 % homozygous compared to the genomes of the outbred domestic cat (24.08 % homozygous), Virunga Mountain Gorilla (78.12 %), inbred Abyssinian cat (62.63 %), Tasmanian devil, domestic dog and other mammalian species. Demographic estimators impute two ancestral population bottlenecks: one >100,000 years ago coincident with cheetah migrations out of the Americas and into Eurasia and Africa, and a second 11,084-12,589 years ago in Africa coincident with late Pleistocene large mammal extinctions. MHC class I gene loss and dramatic reduction in functional diversity of MHC genes would explain why cheetahs ablate skin graft rejection
U2 - 10.1186/s13059-015-0837-4
DO - 10.1186/s13059-015-0837-4
M3 - Article
VL - 16
SP - 277
JO - Genome Biology
JF - Genome Biology
SN - 1474-7596
IS - 1
ER -
ID: 3987005