DOI

  • S. Liu
  • Z. Xiong
  • A.A. Yurchenko
  • K. Krasheninnikova
  • A. Schmidt-Küntzel
  • K.-P. Koepfli
  • W. Johnson
  • L.F.K. Kuderna
  • R. Garc a-Pérez
  • M. Manuel
  • R. Godinez
  • A. Makunin
  • W. Qiu
  • L. Zhou
  • F. Li
  • J. Yi
  • C. Driscoll
  • A. Antunes
  • T.K. Oleksyk
  • E. Eizirik
  • P. Perelman
  • M. Roelke
  • D. Wildt
  • M. Diekhans
  • T. Marques-Bonet
  • L. Marker
  • J. Bhak
  • J. Wang
  • G. Zhang
Background: Patterns of genetic and genomic variance are informative in inferring population history for human, model species and endangered populations.Results: Here the genome sequence of wild-born African cheetahs reveals extreme genomic depletion in SNV incidence, SNV density, SNVs of coding genes, MHC class I and II genes, and mitochondrial DNA SNVs. Cheetah genomes are on average 95 % homozygous compared to the genomes of the outbred domestic cat (24.08 % homozygous), Virunga Mountain Gorilla (78.12 %), inbred Abyssinian cat (62.63 %), Tasmanian devil, domestic dog and other mammalian species. Demographic estimators impute two ancestral population bottlenecks: one >100,000 years ago coincident with cheetah migrations out of the Americas and into Eurasia and Africa, and a second 11,084-12,589 years ago in Africa coincident with late Pleistocene large mammal extinctions. MHC class I gene loss and dramatic reduction in functional diversity of MHC genes would explain why cheetahs ablate skin graft rejection
Язык оригиналаанглийский
Страницы (с-по)277
ЖурналGenome Biology
Том16
Номер выпуска1
DOI
СостояниеОпубликовано - 2015

ID: 3987005