DOI

Human iPSC lines were generated from peripheral blood mononuclear cells of patient carrying LMNA mutation associated with Emery–Dreifuss muscular dystrophy accompanied by atrioventricular block and paroxysmal atrial fibrillation. Reprogramming factors OCT4, KLF4, SOX2, CMYC were delivered using Sendai virus transduction. iPSCs were characterized in order to prove the pluripotency markers expression, normal karyotype, ability to differentiate into three embryonic germ layers. Generated iPSC lines would be useful model to investigate disease development associated with genetic variants in LMNA gene.

Язык оригиналаанглийский
Номер статьи101895
Число страниц5
ЖурналStem Cell Research
Том47
DOI
СостояниеОпубликовано - авг 2020

    Предметные области Scopus

  • Клеточная биология
  • Биология развития

ID: 71709834