Human iPSC lines were generated from peripheral blood mononuclear cells of patient carrying LMNA mutation associated with Emery–Dreifuss muscular dystrophy accompanied by atrioventricular block and paroxysmal atrial fibrillation. Reprogramming factors OCT4, KLF4, SOX2, CMYC were delivered using Sendai virus transduction. iPSCs were characterized in order to prove the pluripotency markers expression, normal karyotype, ability to differentiate into three embryonic germ layers. Generated iPSC lines would be useful model to investigate disease development associated with genetic variants in LMNA gene.

Original languageEnglish
Article number101895
Number of pages5
JournalStem Cell Research
Volume47
DOIs
StatePublished - Aug 2020

    Research areas

  • MUTATIONS

    Scopus subject areas

  • Cell Biology
  • Developmental Biology

ID: 71709834