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Generation of iPSC line from patient with arrhythmogenic right ventricular cardiomyopathy carrying mutations in PKP2 gene. / Khudiakov, Aleksandr; Kostina, Daria; Zlotina, Anna; Yany, Natalia; Sergushichev, Alexey; Pervunina, Tatiana; Tomilin, Alexey; Kostareva, Anna; Malashicheva, Anna.

в: Stem Cell Research, Том 24, 01.10.2017, стр. 85-88.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

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@article{fcc25e40dd984867a55f77217191133d,
title = "Generation of iPSC line from patient with arrhythmogenic right ventricular cardiomyopathy carrying mutations in PKP2 gene",
abstract = "Human iPSC line was generated from patient-specific adipose tissue-derived mesenchymal multipotent stromal cells carrying two mutations in plakophilin-2 (PKP2) gene using non-integrative reprogramming method. Reprogramming factors OCT4, KLF4, SOX2, CMYC were delivered using Sendai viruses. Pluripotency was confirmed in vitro using immunofluorescence and RT-PCR analysis and in vivo by teratoma assay. The reported iPSC line could be useful tool for in vitro modeling of arrhythmogenic right ventricular cardiomyopathy.",
author = "Aleksandr Khudiakov and Daria Kostina and Anna Zlotina and Natalia Yany and Alexey Sergushichev and Tatiana Pervunina and Alexey Tomilin and Anna Kostareva and Anna Malashicheva",
year = "2017",
month = oct,
day = "1",
doi = "10.1016/j.scr.2017.08.014",
language = "English",
volume = "24",
pages = "85--88",
journal = "Stem Cell Research",
issn = "1873-5061",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Generation of iPSC line from patient with arrhythmogenic right ventricular cardiomyopathy carrying mutations in PKP2 gene

AU - Khudiakov, Aleksandr

AU - Kostina, Daria

AU - Zlotina, Anna

AU - Yany, Natalia

AU - Sergushichev, Alexey

AU - Pervunina, Tatiana

AU - Tomilin, Alexey

AU - Kostareva, Anna

AU - Malashicheva, Anna

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Human iPSC line was generated from patient-specific adipose tissue-derived mesenchymal multipotent stromal cells carrying two mutations in plakophilin-2 (PKP2) gene using non-integrative reprogramming method. Reprogramming factors OCT4, KLF4, SOX2, CMYC were delivered using Sendai viruses. Pluripotency was confirmed in vitro using immunofluorescence and RT-PCR analysis and in vivo by teratoma assay. The reported iPSC line could be useful tool for in vitro modeling of arrhythmogenic right ventricular cardiomyopathy.

AB - Human iPSC line was generated from patient-specific adipose tissue-derived mesenchymal multipotent stromal cells carrying two mutations in plakophilin-2 (PKP2) gene using non-integrative reprogramming method. Reprogramming factors OCT4, KLF4, SOX2, CMYC were delivered using Sendai viruses. Pluripotency was confirmed in vitro using immunofluorescence and RT-PCR analysis and in vivo by teratoma assay. The reported iPSC line could be useful tool for in vitro modeling of arrhythmogenic right ventricular cardiomyopathy.

UR - http://www.scopus.com/inward/record.url?scp=85027969100&partnerID=8YFLogxK

U2 - 10.1016/j.scr.2017.08.014

DO - 10.1016/j.scr.2017.08.014

M3 - Article

C2 - 29034900

AN - SCOPUS:85027969100

VL - 24

SP - 85

EP - 88

JO - Stem Cell Research

JF - Stem Cell Research

SN - 1873-5061

ER -

ID: 35806955