Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Generation of iPSC line from patient with arrhythmogenic right ventricular cardiomyopathy carrying mutations in PKP2 gene. / Khudiakov, Aleksandr; Kostina, Daria; Zlotina, Anna; Yany, Natalia; Sergushichev, Alexey; Pervunina, Tatiana; Tomilin, Alexey; Kostareva, Anna; Malashicheva, Anna.
в: Stem Cell Research, Том 24, 01.10.2017, стр. 85-88.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Generation of iPSC line from patient with arrhythmogenic right ventricular cardiomyopathy carrying mutations in PKP2 gene
AU - Khudiakov, Aleksandr
AU - Kostina, Daria
AU - Zlotina, Anna
AU - Yany, Natalia
AU - Sergushichev, Alexey
AU - Pervunina, Tatiana
AU - Tomilin, Alexey
AU - Kostareva, Anna
AU - Malashicheva, Anna
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Human iPSC line was generated from patient-specific adipose tissue-derived mesenchymal multipotent stromal cells carrying two mutations in plakophilin-2 (PKP2) gene using non-integrative reprogramming method. Reprogramming factors OCT4, KLF4, SOX2, CMYC were delivered using Sendai viruses. Pluripotency was confirmed in vitro using immunofluorescence and RT-PCR analysis and in vivo by teratoma assay. The reported iPSC line could be useful tool for in vitro modeling of arrhythmogenic right ventricular cardiomyopathy.
AB - Human iPSC line was generated from patient-specific adipose tissue-derived mesenchymal multipotent stromal cells carrying two mutations in plakophilin-2 (PKP2) gene using non-integrative reprogramming method. Reprogramming factors OCT4, KLF4, SOX2, CMYC were delivered using Sendai viruses. Pluripotency was confirmed in vitro using immunofluorescence and RT-PCR analysis and in vivo by teratoma assay. The reported iPSC line could be useful tool for in vitro modeling of arrhythmogenic right ventricular cardiomyopathy.
UR - http://www.scopus.com/inward/record.url?scp=85027969100&partnerID=8YFLogxK
U2 - 10.1016/j.scr.2017.08.014
DO - 10.1016/j.scr.2017.08.014
M3 - Article
C2 - 29034900
AN - SCOPUS:85027969100
VL - 24
SP - 85
EP - 88
JO - Stem Cell Research
JF - Stem Cell Research
SN - 1873-5061
ER -
ID: 35806955