TY - JOUR

T1 - Facial processing in bipolar disorder is mediated by clinical and biological aspects

AU - Shoshina, Irina

AU - de Oliveira, Milena Edite Casé

AU - Silva, Gabriella Medeiros

AU - Thiago P. , Fernandes

AU - Felisberti, Fatima M

AU - dos Santos, Natanael Antonio

AU - Negreiros, Nathalia S.

PY - 2022/10

Y1 - 2022/10

N2 - Objective: The process of detecting faces can be considered one of the initial steps in face recognition, which is essential for human interaction. We sought to investigate whether a face perception task reliably detects subtle perceptual disturbances between patients with bipolar disorder (BD) and healthy controls. Methods: In this multisite study, we examined differences between BD patients and matched healthy controls. Participants were instructed to detect the orientation (either left or right) of a face when it was presented as a face/non-face pair on a computer screen using Bayesian entropy estimation. Data analyses compared performance between the groups. Results: Overall, BD patients exhibited more perceptual disturbances compared with controls. BD patients who took olanzapine had better performance and faster reaction times (RTs) than patients who took lithium or were medication-naive. BD patients who took lithium had better performance and faster RTs than medication-naive patients. The medication-naive BD group exhibited greater disturbances than all other groups. Conclusion: These findings highlight the reliability of the face perception task used herein and may be important for public health initiatives and follow-up studies that seek to understand the diverse effects of other variables that can affect sensory processing in this population.

AB - Objective: The process of detecting faces can be considered one of the initial steps in face recognition, which is essential for human interaction. We sought to investigate whether a face perception task reliably detects subtle perceptual disturbances between patients with bipolar disorder (BD) and healthy controls. Methods: In this multisite study, we examined differences between BD patients and matched healthy controls. Participants were instructed to detect the orientation (either left or right) of a face when it was presented as a face/non-face pair on a computer screen using Bayesian entropy estimation. Data analyses compared performance between the groups. Results: Overall, BD patients exhibited more perceptual disturbances compared with controls. BD patients who took olanzapine had better performance and faster reaction times (RTs) than patients who took lithium or were medication-naive. BD patients who took lithium had better performance and faster RTs than medication-naive patients. The medication-naive BD group exhibited greater disturbances than all other groups. Conclusion: These findings highlight the reliability of the face perception task used herein and may be important for public health initiatives and follow-up studies that seek to understand the diverse effects of other variables that can affect sensory processing in this population.

KW - bipolar disorder

KW - Medication

KW - Olanzapine

KW - Serum levels

KW - face perception

KW - face detection

UR - https://www.scielo.br/j/rbp/a/D6JKTxCymhRpDCKBp7rBjWB/abstract/?lang=en

M3 - Article

JO - Revista Brasileira de Psiquiatria

JF - Revista Brasileira de Psiquiatria

SN - 1516-4446

ER -