Research output: Contribution to journal › Article › peer-review
Facial processing in bipolar disorder is mediated by clinical and biological aspects. / Shoshina, Irina; de Oliveira, Milena Edite Casé ; Silva, Gabriella Medeiros ; Thiago P. , Fernandes; Felisberti, Fatima M ; dos Santos, Natanael Antonio ; Negreiros, Nathalia S. .
In: Brazilian Journal of Psychiatry, 10.2022.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Facial processing in bipolar disorder is mediated by clinical and biological aspects
AU - Shoshina, Irina
AU - de Oliveira, Milena Edite Casé
AU - Silva, Gabriella Medeiros
AU - Thiago P. , Fernandes
AU - Felisberti, Fatima M
AU - dos Santos, Natanael Antonio
AU - Negreiros, Nathalia S.
PY - 2022/10
Y1 - 2022/10
N2 - Objective: The process of detecting faces can be considered one of the initial steps in face recognition, which is essential for human interaction. We sought to investigate whether a face perception task reliably detects subtle perceptual disturbances between patients with bipolar disorder (BD) and healthy controls. Methods: In this multisite study, we examined differences between BD patients and matched healthy controls. Participants were instructed to detect the orientation (either left or right) of a face when it was presented as a face/non-face pair on a computer screen using Bayesian entropy estimation. Data analyses compared performance between the groups. Results: Overall, BD patients exhibited more perceptual disturbances compared with controls. BD patients who took olanzapine had better performance and faster reaction times (RTs) than patients who took lithium or were medication-naive. BD patients who took lithium had better performance and faster RTs than medication-naive patients. The medication-naive BD group exhibited greater disturbances than all other groups. Conclusion: These findings highlight the reliability of the face perception task used herein and may be important for public health initiatives and follow-up studies that seek to understand the diverse effects of other variables that can affect sensory processing in this population.
AB - Objective: The process of detecting faces can be considered one of the initial steps in face recognition, which is essential for human interaction. We sought to investigate whether a face perception task reliably detects subtle perceptual disturbances between patients with bipolar disorder (BD) and healthy controls. Methods: In this multisite study, we examined differences between BD patients and matched healthy controls. Participants were instructed to detect the orientation (either left or right) of a face when it was presented as a face/non-face pair on a computer screen using Bayesian entropy estimation. Data analyses compared performance between the groups. Results: Overall, BD patients exhibited more perceptual disturbances compared with controls. BD patients who took olanzapine had better performance and faster reaction times (RTs) than patients who took lithium or were medication-naive. BD patients who took lithium had better performance and faster RTs than medication-naive patients. The medication-naive BD group exhibited greater disturbances than all other groups. Conclusion: These findings highlight the reliability of the face perception task used herein and may be important for public health initiatives and follow-up studies that seek to understand the diverse effects of other variables that can affect sensory processing in this population.
KW - bipolar disorder
KW - Medication
KW - Olanzapine
KW - Serum levels
KW - face perception
KW - face detection
UR - https://www.scielo.br/j/rbp/a/D6JKTxCymhRpDCKBp7rBjWB/abstract/?lang=en
M3 - Article
JO - Revista Brasileira de Psiquiatria
JF - Revista Brasileira de Psiquiatria
SN - 1516-4446
ER -
ID: 100591875