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Effect of intravitreal injections and volume changes on intraocular pressure : clinical results and biomechanical model. / Kotliar, Konstantin; Maier, Mathias; Bauer, Svetlana; Feucht, Nikolaus; Lohmann, Chris; Lanzl, Ines.

в: Acta Ophthalmologica Scandinavica, Том 85, № 7, 11.2007, стр. 777-781.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

Harvard

Kotliar, K, Maier, M, Bauer, S, Feucht, N, Lohmann, C & Lanzl, I 2007, 'Effect of intravitreal injections and volume changes on intraocular pressure: clinical results and biomechanical model', Acta Ophthalmologica Scandinavica, Том. 85, № 7, стр. 777-781. https://doi.org/10.1111/j.1600-0420.2007.00939.x

APA

Vancouver

Author

Kotliar, Konstantin ; Maier, Mathias ; Bauer, Svetlana ; Feucht, Nikolaus ; Lohmann, Chris ; Lanzl, Ines. / Effect of intravitreal injections and volume changes on intraocular pressure : clinical results and biomechanical model. в: Acta Ophthalmologica Scandinavica. 2007 ; Том 85, № 7. стр. 777-781.

BibTeX

@article{d551347a7ae54d0a8b02e14e8c88a446,
title = "Effect of intravitreal injections and volume changes on intraocular pressure: clinical results and biomechanical model",
abstract = "Purpose: Intravitreal injections are used extensively to treat retinal diseases. Performing an intravitreal injection increases intraocular volume by the amount of fluid brought into the eye. Whether this influences intraocular pressure (IOP) was investigated here.Methods: A biomechanical model relying on 3-dimensional elasticity theory was developed to determine the short-term effect of volume changes on IOP. We calculated the effect for intravitreal injections of 0.1 ml in myopic, emmetropic and hyperopic eyes. Our calculations were compared with IOP measurements obtained immediately after intravitreal injection of 4 mg triamcinolone in 0.1 ml solution (IVTA) in 22 patients. Shortly after the measurement had been taken, IOP was reduced by paracentesis.Results: Immediately after IVTA, measured IOP was elevated by a mean of 40.6 +/- 12.1 mmHg compared with initial pressure (p < 0.001). Measured and calculated IOP were comparable. Eyes with shorter axial length had higher IOP immediately after the injection (p < 0.05).Conclusions: The effect of injected volumes on IOP can be calculated with a biomechanical model. Our results show that paracentesis might be recommended when injecting 0.1 ml of a substance to avoid a short-term increase in IOP. As intravitreal injections are mostly applied in diseases that are due to vascular compromise, it might be prudent not to impair perfusion in those eyes, even for short periods of time.",
keywords = "Biomechanical model, Intraocular pressure, Intravitreal injection, Triamcinolone",
author = "Konstantin Kotliar and Mathias Maier and Svetlana Bauer and Nikolaus Feucht and Chris Lohmann and Ines Lanzl",
year = "2007",
month = nov,
doi = "10.1111/j.1600-0420.2007.00939.x",
language = "Английский",
volume = "85",
pages = "777--781",
journal = "Acta Ophthalmologica",
issn = "1755-375X",
publisher = "Wiley-Blackwell",
number = "7",

}

RIS

TY - JOUR

T1 - Effect of intravitreal injections and volume changes on intraocular pressure

T2 - clinical results and biomechanical model

AU - Kotliar, Konstantin

AU - Maier, Mathias

AU - Bauer, Svetlana

AU - Feucht, Nikolaus

AU - Lohmann, Chris

AU - Lanzl, Ines

PY - 2007/11

Y1 - 2007/11

N2 - Purpose: Intravitreal injections are used extensively to treat retinal diseases. Performing an intravitreal injection increases intraocular volume by the amount of fluid brought into the eye. Whether this influences intraocular pressure (IOP) was investigated here.Methods: A biomechanical model relying on 3-dimensional elasticity theory was developed to determine the short-term effect of volume changes on IOP. We calculated the effect for intravitreal injections of 0.1 ml in myopic, emmetropic and hyperopic eyes. Our calculations were compared with IOP measurements obtained immediately after intravitreal injection of 4 mg triamcinolone in 0.1 ml solution (IVTA) in 22 patients. Shortly after the measurement had been taken, IOP was reduced by paracentesis.Results: Immediately after IVTA, measured IOP was elevated by a mean of 40.6 +/- 12.1 mmHg compared with initial pressure (p < 0.001). Measured and calculated IOP were comparable. Eyes with shorter axial length had higher IOP immediately after the injection (p < 0.05).Conclusions: The effect of injected volumes on IOP can be calculated with a biomechanical model. Our results show that paracentesis might be recommended when injecting 0.1 ml of a substance to avoid a short-term increase in IOP. As intravitreal injections are mostly applied in diseases that are due to vascular compromise, it might be prudent not to impair perfusion in those eyes, even for short periods of time.

AB - Purpose: Intravitreal injections are used extensively to treat retinal diseases. Performing an intravitreal injection increases intraocular volume by the amount of fluid brought into the eye. Whether this influences intraocular pressure (IOP) was investigated here.Methods: A biomechanical model relying on 3-dimensional elasticity theory was developed to determine the short-term effect of volume changes on IOP. We calculated the effect for intravitreal injections of 0.1 ml in myopic, emmetropic and hyperopic eyes. Our calculations were compared with IOP measurements obtained immediately after intravitreal injection of 4 mg triamcinolone in 0.1 ml solution (IVTA) in 22 patients. Shortly after the measurement had been taken, IOP was reduced by paracentesis.Results: Immediately after IVTA, measured IOP was elevated by a mean of 40.6 +/- 12.1 mmHg compared with initial pressure (p < 0.001). Measured and calculated IOP were comparable. Eyes with shorter axial length had higher IOP immediately after the injection (p < 0.05).Conclusions: The effect of injected volumes on IOP can be calculated with a biomechanical model. Our results show that paracentesis might be recommended when injecting 0.1 ml of a substance to avoid a short-term increase in IOP. As intravitreal injections are mostly applied in diseases that are due to vascular compromise, it might be prudent not to impair perfusion in those eyes, even for short periods of time.

KW - Biomechanical model

KW - Intraocular pressure

KW - Intravitreal injection

KW - Triamcinolone

UR - http://www.scopus.com/inward/record.url?scp=35448934930&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0420.2007.00939.x

DO - 10.1111/j.1600-0420.2007.00939.x

M3 - статья

C2 - 17573861

AN - SCOPUS:35448934930

VL - 85

SP - 777

EP - 781

JO - Acta Ophthalmologica

JF - Acta Ophthalmologica

SN - 1755-375X

IS - 7

ER -

ID: 9116959