Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
Diversity of Nuclear Lamin A/C Action as a Key to Tissue-Specific Regulation of Cellular Identity in Health and Disease. / Malashicheva, Anna; Perepelina, Kseniya.
в: Frontiers in Cell and Developmental Biology, Том 9, 761469, 13.10.2021.Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
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TY - JOUR
T1 - Diversity of Nuclear Lamin A/C Action as a Key to Tissue-Specific Regulation of Cellular Identity in Health and Disease
AU - Malashicheva, Anna
AU - Perepelina, Kseniya
N1 - Publisher Copyright: © Copyright © 2021 Malashicheva and Perepelina.
PY - 2021/10/13
Y1 - 2021/10/13
N2 - A-type lamins are the main structural components of the nucleus, which are mainly localized at the nucleus periphery. First of all, A-type lamins, together with B-type lamins and proteins of the inner nuclear membrane, form a stiff structure—the nuclear lamina. Besides maintaining the nucleus cell shape, A-type lamins play a critical role in many cellular events, such as gene transcription and epigenetic regulation. Nowadays it is clear that lamins play a very important role in determining cell fate decisions. Various mutations in genes encoding A-type lamins lead to damages of different types of tissues in humans, collectively known as laminopathies, and it is clear that A-type lamins are involved in the regulation of cell differentiation and stemness. However, the mechanisms of this regulation remain unclear. In this review, we discuss how A-type lamins can execute their regulatory role in determining the differentiation status of a cell. We have summarized recent data focused on lamin A/C action mechanisms in regulation of cell differentiation and identity development of stem cells of different origin. We also discuss how this knowledge can promote further research toward a deeper understanding of the role of lamin A/C mutations in laminopathies.
AB - A-type lamins are the main structural components of the nucleus, which are mainly localized at the nucleus periphery. First of all, A-type lamins, together with B-type lamins and proteins of the inner nuclear membrane, form a stiff structure—the nuclear lamina. Besides maintaining the nucleus cell shape, A-type lamins play a critical role in many cellular events, such as gene transcription and epigenetic regulation. Nowadays it is clear that lamins play a very important role in determining cell fate decisions. Various mutations in genes encoding A-type lamins lead to damages of different types of tissues in humans, collectively known as laminopathies, and it is clear that A-type lamins are involved in the regulation of cell differentiation and stemness. However, the mechanisms of this regulation remain unclear. In this review, we discuss how A-type lamins can execute their regulatory role in determining the differentiation status of a cell. We have summarized recent data focused on lamin A/C action mechanisms in regulation of cell differentiation and identity development of stem cells of different origin. We also discuss how this knowledge can promote further research toward a deeper understanding of the role of lamin A/C mutations in laminopathies.
KW - cell differentiation
KW - chromatin organization
KW - LADs
KW - lamin A/C
KW - laminopathies
KW - LMNA gene
KW - regulation of gene expression
KW - LMNA MUTATION
KW - MEMBRANE PROTEINS
KW - STEM-CELLS
KW - C
KW - CHROMATIN
KW - A-TYPE LAMINS
KW - lamin A
KW - MUSCULAR-DYSTROPHY
KW - DILATED CARDIOMYOPATHY
KW - MISSENSE MUTATIONS
KW - IN-VITRO
KW - MOUSE MODEL
UR - http://www.scopus.com/inward/record.url?scp=85118151914&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/59938abb-f525-38b6-ba4c-f171b9bf47db/
U2 - 10.3389/fcell.2021.761469
DO - 10.3389/fcell.2021.761469
M3 - Review article
AN - SCOPUS:85118151914
VL - 9
JO - Frontiers in Cell and Developmental Biology
JF - Frontiers in Cell and Developmental Biology
SN - 2296-634X
M1 - 761469
ER -
ID: 87928638