Diversity of Nuclear Lamin A/C Action as a Key to Tissue-Specific Regulation of Cellular Identity in Health and Disease

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Diversity of Nuclear Lamin A/C Action as a Key to Tissue-Specific Regulation of Cellular Identity in Health and Disease. / Malashicheva, Anna ; Perepelina, Kseniya.

In: Frontiers in Cell and Developmental Biology, Vol. 9, 761469, 13.10.2021.

Research output: Contribution to journal › Review article › peer-review

BibTeX

@article{969eea1eb71b4caf8c45aa440adde764,

title = "Diversity of Nuclear Lamin A/C Action as a Key to Tissue-Specific Regulation of Cellular Identity in Health and Disease",

abstract = "A-type lamins are the main structural components of the nucleus, which are mainly localized at the nucleus periphery. First of all, A-type lamins, together with B-type lamins and proteins of the inner nuclear membrane, form a stiff structure—the nuclear lamina. Besides maintaining the nucleus cell shape, A-type lamins play a critical role in many cellular events, such as gene transcription and epigenetic regulation. Nowadays it is clear that lamins play a very important role in determining cell fate decisions. Various mutations in genes encoding A-type lamins lead to damages of different types of tissues in humans, collectively known as laminopathies, and it is clear that A-type lamins are involved in the regulation of cell differentiation and stemness. However, the mechanisms of this regulation remain unclear. In this review, we discuss how A-type lamins can execute their regulatory role in determining the differentiation status of a cell. We have summarized recent data focused on lamin A/C action mechanisms in regulation of cell differentiation and identity development of stem cells of different origin. We also discuss how this knowledge can promote further research toward a deeper understanding of the role of lamin A/C mutations in laminopathies.",

keywords = "cell differentiation, chromatin organization, LADs, lamin A/C, laminopathies, LMNA gene, regulation of gene expression, LMNA MUTATION, MEMBRANE PROTEINS, STEM-CELLS, C, CHROMATIN, A-TYPE LAMINS, lamin A, MUSCULAR-DYSTROPHY, DILATED CARDIOMYOPATHY, MISSENSE MUTATIONS, IN-VITRO, MOUSE MODEL",

author = "Anna Malashicheva and Kseniya Perepelina",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Malashicheva and Perepelina.",

year = "2021",

month = oct,

day = "13",

doi = "10.3389/fcell.2021.761469",

language = "English",

volume = "9",

journal = "Frontiers in Cell and Developmental Biology",

issn = "2296-634X",

publisher = "JMIR PUBLICATIONS, INC",

}

RIS

TY - JOUR

T1 - Diversity of Nuclear Lamin A/C Action as a Key to Tissue-Specific Regulation of Cellular Identity in Health and Disease

AU - Malashicheva, Anna

AU - Perepelina, Kseniya

PY - 2021/10/13

Y1 - 2021/10/13

N2 - A-type lamins are the main structural components of the nucleus, which are mainly localized at the nucleus periphery. First of all, A-type lamins, together with B-type lamins and proteins of the inner nuclear membrane, form a stiff structure—the nuclear lamina. Besides maintaining the nucleus cell shape, A-type lamins play a critical role in many cellular events, such as gene transcription and epigenetic regulation. Nowadays it is clear that lamins play a very important role in determining cell fate decisions. Various mutations in genes encoding A-type lamins lead to damages of different types of tissues in humans, collectively known as laminopathies, and it is clear that A-type lamins are involved in the regulation of cell differentiation and stemness. However, the mechanisms of this regulation remain unclear. In this review, we discuss how A-type lamins can execute their regulatory role in determining the differentiation status of a cell. We have summarized recent data focused on lamin A/C action mechanisms in regulation of cell differentiation and identity development of stem cells of different origin. We also discuss how this knowledge can promote further research toward a deeper understanding of the role of lamin A/C mutations in laminopathies.

AB - A-type lamins are the main structural components of the nucleus, which are mainly localized at the nucleus periphery. First of all, A-type lamins, together with B-type lamins and proteins of the inner nuclear membrane, form a stiff structure—the nuclear lamina. Besides maintaining the nucleus cell shape, A-type lamins play a critical role in many cellular events, such as gene transcription and epigenetic regulation. Nowadays it is clear that lamins play a very important role in determining cell fate decisions. Various mutations in genes encoding A-type lamins lead to damages of different types of tissues in humans, collectively known as laminopathies, and it is clear that A-type lamins are involved in the regulation of cell differentiation and stemness. However, the mechanisms of this regulation remain unclear. In this review, we discuss how A-type lamins can execute their regulatory role in determining the differentiation status of a cell. We have summarized recent data focused on lamin A/C action mechanisms in regulation of cell differentiation and identity development of stem cells of different origin. We also discuss how this knowledge can promote further research toward a deeper understanding of the role of lamin A/C mutations in laminopathies.

KW - cell differentiation

KW - chromatin organization

KW - LADs

KW - lamin A/C

KW - laminopathies

KW - LMNA gene

KW - regulation of gene expression

KW - LMNA MUTATION

KW - MEMBRANE PROTEINS

KW - STEM-CELLS

KW - C

KW - CHROMATIN

KW - A-TYPE LAMINS

KW - lamin A

KW - MUSCULAR-DYSTROPHY

KW - DILATED CARDIOMYOPATHY

KW - MISSENSE MUTATIONS

KW - IN-VITRO

KW - MOUSE MODEL

UR - http://www.scopus.com/inward/record.url?scp=85118151914&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/59938abb-f525-38b6-ba4c-f171b9bf47db/

U2 - 10.3389/fcell.2021.761469

DO - 10.3389/fcell.2021.761469

M3 - Review article

AN - SCOPUS:85118151914

VL - 9

JO - Frontiers in Cell and Developmental Biology

JF - Frontiers in Cell and Developmental Biology

SN - 2296-634X

M1 - 761469

ER -

ID: 87928638