Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Distinct effect of xenobiotics on the metal-binding properties of protein molecules. / Novikova, Natalia; Kovalchuk, Mikhail; Stepina, Nina; Gaynutdinov, Radmir; Chukhrai, Elena; Yurieva, Eleonora.
в: Journal of Synchrotron Radiation, Том 22, 01.07.2015, стр. 1001-1007.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Distinct effect of xenobiotics on the metal-binding properties of protein molecules
AU - Novikova, Natalia
AU - Kovalchuk, Mikhail
AU - Stepina, Nina
AU - Gaynutdinov, Radmir
AU - Chukhrai, Elena
AU - Yurieva, Eleonora
N1 - Publisher Copyright: © 2015 International Union of Crystallography.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - The X-ray standing-wave method was applied to study the elemental composition and molecular organization of ordered protein films of alkaline phosphatase exposed to different xenobiotics (drug compounds, lead). Binding of metal ions from triply distilled water to protein molecules has been experimentally observed. Definite differences in the arrangement of impurity metal ions in the films have been established. The considerable enhancement of protein-metal interactions is attributed to partial rearrangement of the protein native structure, induced by xenobiotics.
AB - The X-ray standing-wave method was applied to study the elemental composition and molecular organization of ordered protein films of alkaline phosphatase exposed to different xenobiotics (drug compounds, lead). Binding of metal ions from triply distilled water to protein molecules has been experimentally observed. Definite differences in the arrangement of impurity metal ions in the films have been established. The considerable enhancement of protein-metal interactions is attributed to partial rearrangement of the protein native structure, induced by xenobiotics.
KW - alkaline phosphatase
KW - chelating drug compounds
KW - Langmuir-Blodgett monolayer
KW - trace metal binding
KW - X-ray fluorescence
KW - X-ray total external reflection
UR - http://www.scopus.com/inward/record.url?scp=84937429290&partnerID=8YFLogxK
U2 - 10.1107/S1600577515005627
DO - 10.1107/S1600577515005627
M3 - Article
C2 - 26134804
AN - SCOPUS:84937429290
VL - 22
SP - 1001
EP - 1007
JO - Journal of Synchrotron Radiation
JF - Journal of Synchrotron Radiation
SN - 0909-0495
ER -
ID: 88206261