Distinct effect of xenobiotics on the metal-binding properties of protein molecules

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Distinct effect of xenobiotics on the metal-binding properties of protein molecules. / Novikova, Natalia; Kovalchuk, Mikhail; Stepina, Nina; Gaynutdinov, Radmir; Chukhrai, Elena; Yurieva, Eleonora.

In: Journal of Synchrotron Radiation, Vol. 22, 01.07.2015, p. 1001-1007.

Research output: Contribution to journal › Article › peer-review

Author

Novikova, Natalia ; Kovalchuk, Mikhail ; Stepina, Nina ; Gaynutdinov, Radmir ; Chukhrai, Elena ; Yurieva, Eleonora. / Distinct effect of xenobiotics on the metal-binding properties of protein molecules. In: Journal of Synchrotron Radiation. 2015 ; Vol. 22. pp. 1001-1007.

BibTeX

@article{3439564025064241be81d3e643c8d011,

title = "Distinct effect of xenobiotics on the metal-binding properties of protein molecules",

abstract = "The X-ray standing-wave method was applied to study the elemental composition and molecular organization of ordered protein films of alkaline phosphatase exposed to different xenobiotics (drug compounds, lead). Binding of metal ions from triply distilled water to protein molecules has been experimentally observed. Definite differences in the arrangement of impurity metal ions in the films have been established. The considerable enhancement of protein-metal interactions is attributed to partial rearrangement of the protein native structure, induced by xenobiotics.",

keywords = "alkaline phosphatase, chelating drug compounds, Langmuir-Blodgett monolayer, trace metal binding, X-ray fluorescence, X-ray total external reflection",

author = "Natalia Novikova and Mikhail Kovalchuk and Nina Stepina and Radmir Gaynutdinov and Elena Chukhrai and Eleonora Yurieva",

note = "Publisher Copyright: {\textcopyright} 2015 International Union of Crystallography.",

year = "2015",

month = jul,

day = "1",

doi = "10.1107/S1600577515005627",

language = "English",

volume = "22",

pages = "1001--1007",

journal = "Journal of Synchrotron Radiation",

issn = "0909-0495",

publisher = "International Union of Crystallography",

}

RIS

TY - JOUR

T1 - Distinct effect of xenobiotics on the metal-binding properties of protein molecules

AU - Novikova, Natalia

AU - Kovalchuk, Mikhail

AU - Stepina, Nina

AU - Gaynutdinov, Radmir

AU - Chukhrai, Elena

AU - Yurieva, Eleonora

PY - 2015/7/1

Y1 - 2015/7/1

N2 - The X-ray standing-wave method was applied to study the elemental composition and molecular organization of ordered protein films of alkaline phosphatase exposed to different xenobiotics (drug compounds, lead). Binding of metal ions from triply distilled water to protein molecules has been experimentally observed. Definite differences in the arrangement of impurity metal ions in the films have been established. The considerable enhancement of protein-metal interactions is attributed to partial rearrangement of the protein native structure, induced by xenobiotics.

AB - The X-ray standing-wave method was applied to study the elemental composition and molecular organization of ordered protein films of alkaline phosphatase exposed to different xenobiotics (drug compounds, lead). Binding of metal ions from triply distilled water to protein molecules has been experimentally observed. Definite differences in the arrangement of impurity metal ions in the films have been established. The considerable enhancement of protein-metal interactions is attributed to partial rearrangement of the protein native structure, induced by xenobiotics.

KW - alkaline phosphatase

KW - chelating drug compounds

KW - Langmuir-Blodgett monolayer

KW - trace metal binding

KW - X-ray fluorescence

KW - X-ray total external reflection

UR - http://www.scopus.com/inward/record.url?scp=84937429290&partnerID=8YFLogxK

U2 - 10.1107/S1600577515005627

DO - 10.1107/S1600577515005627

M3 - Article

C2 - 26134804

AN - SCOPUS:84937429290

VL - 22

SP - 1001

EP - 1007

JO - Journal of Synchrotron Radiation

JF - Journal of Synchrotron Radiation

SN - 0909-0495

ER -

ID: 88206261