The possibility of the application of the R.L. Muller model of the microheterogeneous structure of glass for the description of the nature of the conduction various glass classes, the electric conduction of which is due to the migration of cations, anions and the combined migration of cations and electrons, has been considered. It was shown that the appearance and the subsequent increase in the ionic conduction can be explained using the concentration variation of the blocking extent function (γ), which is calculated based on the analysis of the ratio of the concentration of nonpolar and polar structural fragments—structural-chemical units in the bulk of glass. On the whole, the methodology of the calculation of the concentration γ values for various glass systems coincides, except for some features in halogen-containing systems that required additional specifications.