Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
DARK Classics in Chemical Neuroscience : Atropine, Scopolamine, and Other Anticholinergic Deliriant Hallucinogens. / Lakstygal, Anton M.; Kolesnikova, Tatiana O.; Khatsko, Sergey L.; Zabegalov, Konstantin N.; Volgin, Andrey D.; Demin, Konstantin A.; Shevyrin, Vadim A.; Wappler-Guzzetta, Edina A.; Kalueff, Allan V.
в: ACS Chemical Neuroscience, Том 10, № 5, 15.05.2019, стр. 2144-2159.Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
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TY - JOUR
T1 - DARK Classics in Chemical Neuroscience
T2 - Atropine, Scopolamine, and Other Anticholinergic Deliriant Hallucinogens
AU - Lakstygal, Anton M.
AU - Kolesnikova, Tatiana O.
AU - Khatsko, Sergey L.
AU - Zabegalov, Konstantin N.
AU - Volgin, Andrey D.
AU - Demin, Konstantin A.
AU - Shevyrin, Vadim A.
AU - Wappler-Guzzetta, Edina A.
AU - Kalueff, Allan V.
PY - 2019/5/15
Y1 - 2019/5/15
N2 - Anticholinergic drugs based on tropane alkaloids, including atropine, scopolamine, and hyoscyamine, have been used for various medicinal and toxic purposes for millennia. These drugs are competitive antagonists of acetylcholine muscarinic (M-) receptors that potently modulate the central nervous system (CNS). Currently used clinically to treat vomiting, nausea, and bradycardia, as well as alongside other anesthetics to avoid vagal inhibition, these drugs also evoke potent psychotropic effects, including characteristic delirium-like states with hallucinations, altered mood, and cognitive deficits. Given the growing clinical importance of anti-M deliriant hallucinogens, here we discuss their use and abuse, clinical importance, and the growing value in preclinical (experimental) animal models relevant to modeling CNS functions and dysfunctions.
AB - Anticholinergic drugs based on tropane alkaloids, including atropine, scopolamine, and hyoscyamine, have been used for various medicinal and toxic purposes for millennia. These drugs are competitive antagonists of acetylcholine muscarinic (M-) receptors that potently modulate the central nervous system (CNS). Currently used clinically to treat vomiting, nausea, and bradycardia, as well as alongside other anesthetics to avoid vagal inhibition, these drugs also evoke potent psychotropic effects, including characteristic delirium-like states with hallucinations, altered mood, and cognitive deficits. Given the growing clinical importance of anti-M deliriant hallucinogens, here we discuss their use and abuse, clinical importance, and the growing value in preclinical (experimental) animal models relevant to modeling CNS functions and dysfunctions.
KW - antimuscarinic effects
KW - atropine
KW - Cholinergic system
KW - deliriant drugs
KW - hallucinogens
KW - scopolamine
KW - ANTIDEPRESSANT
KW - MEMORY IMPAIRMENT
KW - SEXUAL-BEHAVIOR
KW - BIPERIDEN
KW - PRESCRIPTION DRUG
KW - DOPAMINE TRANSPORTER
KW - BENZTROPINE ANALOGS
KW - TROPANE ALKALOIDS
KW - INDUCED PSYCHOSIS
KW - MUSCARINIC RECEPTOR ANTAGONISTS
UR - http://www.scopus.com/inward/record.url?scp=85060058763&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/dark-classics-chemical-neuroscience-atropine-scopolamine-other-anticholinergic-deliriant-hallucinoge
U2 - 10.1021/acschemneuro.8b00615
DO - 10.1021/acschemneuro.8b00615
M3 - Review article
C2 - 30566832
AN - SCOPUS:85060058763
VL - 10
SP - 2144
EP - 2159
JO - ACS Chemical Neuroscience
JF - ACS Chemical Neuroscience
SN - 1948-7193
IS - 5
ER -
ID: 47608364