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DARK Classics in Chemical Neuroscience : Atropine, Scopolamine, and Other Anticholinergic Deliriant Hallucinogens. / Lakstygal, Anton M.; Kolesnikova, Tatiana O.; Khatsko, Sergey L.; Zabegalov, Konstantin N.; Volgin, Andrey D.; Demin, Konstantin A.; Shevyrin, Vadim A.; Wappler-Guzzetta, Edina A.; Kalueff, Allan V.

In: ACS Chemical Neuroscience, Vol. 10, No. 5, 15.05.2019, p. 2144-2159.

Research output: Contribution to journal › Review article › peer-review

Author

Lakstygal, Anton M. ; Kolesnikova, Tatiana O. ; Khatsko, Sergey L. ; Zabegalov, Konstantin N. ; Volgin, Andrey D. ; Demin, Konstantin A. ; Shevyrin, Vadim A. ; Wappler-Guzzetta, Edina A. ; Kalueff, Allan V. / DARK Classics in Chemical Neuroscience : Atropine, Scopolamine, and Other Anticholinergic Deliriant Hallucinogens. In: ACS Chemical Neuroscience. 2019 ; Vol. 10, No. 5. pp. 2144-2159.

BibTeX

@article{3e1d35f7f79446409a427ba5e57d32bc,

title = "DARK Classics in Chemical Neuroscience: Atropine, Scopolamine, and Other Anticholinergic Deliriant Hallucinogens",

abstract = "Anticholinergic drugs based on tropane alkaloids, including atropine, scopolamine, and hyoscyamine, have been used for various medicinal and toxic purposes for millennia. These drugs are competitive antagonists of acetylcholine muscarinic (M-) receptors that potently modulate the central nervous system (CNS). Currently used clinically to treat vomiting, nausea, and bradycardia, as well as alongside other anesthetics to avoid vagal inhibition, these drugs also evoke potent psychotropic effects, including characteristic delirium-like states with hallucinations, altered mood, and cognitive deficits. Given the growing clinical importance of anti-M deliriant hallucinogens, here we discuss their use and abuse, clinical importance, and the growing value in preclinical (experimental) animal models relevant to modeling CNS functions and dysfunctions.",

keywords = "antimuscarinic effects, atropine, Cholinergic system, deliriant drugs, hallucinogens, scopolamine, ANTIDEPRESSANT, MEMORY IMPAIRMENT, SEXUAL-BEHAVIOR, BIPERIDEN, PRESCRIPTION DRUG, DOPAMINE TRANSPORTER, BENZTROPINE ANALOGS, TROPANE ALKALOIDS, INDUCED PSYCHOSIS, MUSCARINIC RECEPTOR ANTAGONISTS",

author = "Lakstygal, {Anton M.} and Kolesnikova, {Tatiana O.} and Khatsko, {Sergey L.} and Zabegalov, {Konstantin N.} and Volgin, {Andrey D.} and Demin, {Konstantin A.} and Shevyrin, {Vadim A.} and Wappler-Guzzetta, {Edina A.} and Kalueff, {Allan V.}",

year = "2019",

month = may,

day = "15",

doi = "10.1021/acschemneuro.8b00615",

language = "English",

volume = "10",

pages = "2144--2159",

journal = "ACS Chemical Neuroscience",

issn = "1948-7193",

publisher = "American Chemical Society",

number = "5",

}

RIS

TY - JOUR

T1 - DARK Classics in Chemical Neuroscience

T2 - Atropine, Scopolamine, and Other Anticholinergic Deliriant Hallucinogens

AU - Lakstygal, Anton M.

AU - Kolesnikova, Tatiana O.

AU - Khatsko, Sergey L.

AU - Zabegalov, Konstantin N.

AU - Volgin, Andrey D.

AU - Demin, Konstantin A.

AU - Shevyrin, Vadim A.

AU - Wappler-Guzzetta, Edina A.

AU - Kalueff, Allan V.

PY - 2019/5/15

Y1 - 2019/5/15

N2 - Anticholinergic drugs based on tropane alkaloids, including atropine, scopolamine, and hyoscyamine, have been used for various medicinal and toxic purposes for millennia. These drugs are competitive antagonists of acetylcholine muscarinic (M-) receptors that potently modulate the central nervous system (CNS). Currently used clinically to treat vomiting, nausea, and bradycardia, as well as alongside other anesthetics to avoid vagal inhibition, these drugs also evoke potent psychotropic effects, including characteristic delirium-like states with hallucinations, altered mood, and cognitive deficits. Given the growing clinical importance of anti-M deliriant hallucinogens, here we discuss their use and abuse, clinical importance, and the growing value in preclinical (experimental) animal models relevant to modeling CNS functions and dysfunctions.

AB - Anticholinergic drugs based on tropane alkaloids, including atropine, scopolamine, and hyoscyamine, have been used for various medicinal and toxic purposes for millennia. These drugs are competitive antagonists of acetylcholine muscarinic (M-) receptors that potently modulate the central nervous system (CNS). Currently used clinically to treat vomiting, nausea, and bradycardia, as well as alongside other anesthetics to avoid vagal inhibition, these drugs also evoke potent psychotropic effects, including characteristic delirium-like states with hallucinations, altered mood, and cognitive deficits. Given the growing clinical importance of anti-M deliriant hallucinogens, here we discuss their use and abuse, clinical importance, and the growing value in preclinical (experimental) animal models relevant to modeling CNS functions and dysfunctions.

KW - antimuscarinic effects

KW - atropine

KW - Cholinergic system

KW - deliriant drugs

KW - hallucinogens

KW - scopolamine

KW - ANTIDEPRESSANT

KW - MEMORY IMPAIRMENT

KW - SEXUAL-BEHAVIOR

KW - BIPERIDEN

KW - PRESCRIPTION DRUG

KW - DOPAMINE TRANSPORTER

KW - BENZTROPINE ANALOGS

KW - TROPANE ALKALOIDS

KW - INDUCED PSYCHOSIS

KW - MUSCARINIC RECEPTOR ANTAGONISTS

UR - http://www.scopus.com/inward/record.url?scp=85060058763&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/dark-classics-chemical-neuroscience-atropine-scopolamine-other-anticholinergic-deliriant-hallucinoge

U2 - 10.1021/acschemneuro.8b00615

DO - 10.1021/acschemneuro.8b00615

M3 - Review article

C2 - 30566832

AN - SCOPUS:85060058763

VL - 10

SP - 2144

EP - 2159

JO - ACS Chemical Neuroscience

JF - ACS Chemical Neuroscience

SN - 1948-7193

IS - 5

ER -

ID: 47608364

DARK Classics in Chemical Neuroscience: Atropine, Scopolamine, and Other Anticholinergic Deliriant Hallucinogens

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