Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
DARK Classics in Chemical Neuroscience : Kava. / Volgin, Andrey; Yang, LongEn; Amstislavskaya, Tamara; Demin, Konstantin; Wang, Dongmei; Yan, Dongni; Wang, Jingtao; Wang, Mengyao; Alpyshov, Erik; Hu, Guojun; Serikuly, Nazar; Shevyrin, Vadim; Wappler-Guzzetta, Edina; de Abreu, Murilo; Kalueff, Allan.
в: ACS Chemical Neuroscience, 2020.Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
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TY - JOUR
T1 - DARK Classics in Chemical Neuroscience
T2 - Kava
AU - Volgin, Andrey
AU - Yang, LongEn
AU - Amstislavskaya, Tamara
AU - Demin, Konstantin
AU - Wang, Dongmei
AU - Yan, Dongni
AU - Wang, Jingtao
AU - Wang, Mengyao
AU - Alpyshov, Erik
AU - Hu, Guojun
AU - Serikuly, Nazar
AU - Shevyrin, Vadim
AU - Wappler-Guzzetta, Edina
AU - de Abreu, Murilo
AU - Kalueff, Allan
N1 - Publisher Copyright: Copyright © 2020 American Chemical Society.
PY - 2020
Y1 - 2020
N2 - Kava (kava kava, Piper methysticum) is a common drug-containing plant in the Pacific islands. Kavalactones, its psychoactive compounds, exert potent central nervous system (CNS) action clinically and in animal models. However, the exact pharmacological profiles and mechanisms of action of kava on the brain and behavior remain poorly understood. Here, we discuss clinical and experimental data on kava psychopharmacology and summarize chemistry and synthesis of kavalactones. We also review its societal impact, drug use and abuse potential, and future perspectives on translational kava research.
AB - Kava (kava kava, Piper methysticum) is a common drug-containing plant in the Pacific islands. Kavalactones, its psychoactive compounds, exert potent central nervous system (CNS) action clinically and in animal models. However, the exact pharmacological profiles and mechanisms of action of kava on the brain and behavior remain poorly understood. Here, we discuss clinical and experimental data on kava psychopharmacology and summarize chemistry and synthesis of kavalactones. We also review its societal impact, drug use and abuse potential, and future perspectives on translational kava research.
KW - anxiolysis
KW - kava
KW - kavalactones
KW - translational drug research
UR - http://www.scopus.com/inward/record.url?scp=85078892956&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/c84bb678-3d61-38aa-ab61-230f986363ee/
U2 - 10.1021/acschemneuro.9b00587
DO - 10.1021/acschemneuro.9b00587
M3 - Review article
C2 - 31904216
JO - ACS Chemical Neuroscience
JF - ACS Chemical Neuroscience
SN - 1948-7193
ER -
ID: 51621350