Oceanithermus profundus Miroshnichenko et al. 2003 is the type species of the genus Ocea-nithermus, which belongs to the family Thermaceae. The genus currently comprises two spe-cies whose members are thermophilic and are able to reduce sulfur compounds and nitrite. The organism is adapted to the salinity of sea water, is able to utilize a broad range of carbo-hydrates, some proteinaceous substrates, organic acids and alcohols. This is the first com-pleted genome sequence of a member of the genus Oceanithermus and the fourth sequence from the family Thermaceae. The 2,439,291 bp long genome with its 2,391 protein-coding and 54 RNA genes consists of one chromosome and a 135,351 bp long plasmid, and is a part of the Genomic Encyclopedia of Bacteria and Archaea project.