Comparison CCR5del32 mutation in the CCR5 gene frequencies in Russians, Tuvinians, and in groups of HIV-infected individuals

Standard

Comparison CCR5del32 mutation in the CCR5 gene frequencies in Russians, Tuvinians, and in groups of HIV-infected individuals. / Apryatin, S. A.; Rakhmanaliev, E. R.; Nikolaeva, I. A.; Ruban, S. V.; Vazykhova, F. G.; Klimov, E. A.; Sulimova, G. E.; Sidorovich, I. G.

в: Russian Journal of Genetics, Том 41, № 11, 01.11.2005, стр. 1287-1290.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Author

Apryatin, S. A. ; Rakhmanaliev, E. R. ; Nikolaeva, I. A. ; Ruban, S. V. ; Vazykhova, F. G. ; Klimov, E. A. ; Sulimova, G. E. ; Sidorovich, I. G. / Comparison CCR5del32 mutation in the CCR5 gene frequencies in Russians, Tuvinians, and in groups of HIV-infected individuals. в: Russian Journal of Genetics. 2005 ; Том 41, № 11. стр. 1287-1290.

BibTeX

@article{4a28642036a844cfb18a506380bfb03c,

title = "Comparison CCR5del32 mutation in the CCR5 gene frequencies in Russians, Tuvinians, and in groups of HIV-infected individuals",

abstract = "The 32-bp deletion (CCR5del32 mutation) in the CCR5 (chemokine (C-C motif) receptor 5) gene, encoding CCR5 chemokine receptor, is one of the factors determining natural resistance to human immunodeficiency virus (HIV-1) infection. In the present study, the samples of Russians (n = 102), Tuvinians (n = 50), and HIV-infected individuals (n = 107) were examined for the presence of CCR5del32 mutation in the CCR5 gene. The CCR5del32 allele frequency in Russians and Tuvinians constituted 7.84 and 2%, respectively. Among HIV-1 infected individuals, two groups, of macrophage-tropic HIV-1 strain- and T-cell-tropic HIV-1 strain-infected were distinguished. The CCR5del32 allele frequency in the first group (6.45%) was lower than in the second one (8.73%). Statistical treatment of the HIV-1 infected individuals typing data showed that the difference in the CCR5del32 allele frequencies between the groups of sexually (macrophage-tropic) and parenterally (T-cell-tropic) infected individuals observed was within the limit of random deviation. {\textcopyright} 2005 Pleiades Publishing, Inc.",

author = "Apryatin, {S. A.} and Rakhmanaliev, {E. R.} and Nikolaeva, {I. A.} and Ruban, {S. V.} and Vazykhova, {F. G.} and Klimov, {E. A.} and Sulimova, {G. E.} and Sidorovich, {I. G.}",

year = "2005",

month = nov,

day = "1",

doi = "10.1007/s11177-005-0230-6",

language = "English",

volume = "41",

pages = "1287--1290",

journal = "Russian Journal of Genetics",

issn = "1022-7954",

publisher = "МАИК {"}Наука/Интерпериодика{"}",

number = "11",

}

RIS

TY - JOUR

T1 - Comparison CCR5del32 mutation in the CCR5 gene frequencies in Russians, Tuvinians, and in groups of HIV-infected individuals

AU - Apryatin, S. A.

AU - Rakhmanaliev, E. R.

AU - Nikolaeva, I. A.

AU - Ruban, S. V.

AU - Vazykhova, F. G.

AU - Klimov, E. A.

AU - Sulimova, G. E.

AU - Sidorovich, I. G.

PY - 2005/11/1

Y1 - 2005/11/1

N2 - The 32-bp deletion (CCR5del32 mutation) in the CCR5 (chemokine (C-C motif) receptor 5) gene, encoding CCR5 chemokine receptor, is one of the factors determining natural resistance to human immunodeficiency virus (HIV-1) infection. In the present study, the samples of Russians (n = 102), Tuvinians (n = 50), and HIV-infected individuals (n = 107) were examined for the presence of CCR5del32 mutation in the CCR5 gene. The CCR5del32 allele frequency in Russians and Tuvinians constituted 7.84 and 2%, respectively. Among HIV-1 infected individuals, two groups, of macrophage-tropic HIV-1 strain- and T-cell-tropic HIV-1 strain-infected were distinguished. The CCR5del32 allele frequency in the first group (6.45%) was lower than in the second one (8.73%). Statistical treatment of the HIV-1 infected individuals typing data showed that the difference in the CCR5del32 allele frequencies between the groups of sexually (macrophage-tropic) and parenterally (T-cell-tropic) infected individuals observed was within the limit of random deviation. © 2005 Pleiades Publishing, Inc.

AB - The 32-bp deletion (CCR5del32 mutation) in the CCR5 (chemokine (C-C motif) receptor 5) gene, encoding CCR5 chemokine receptor, is one of the factors determining natural resistance to human immunodeficiency virus (HIV-1) infection. In the present study, the samples of Russians (n = 102), Tuvinians (n = 50), and HIV-infected individuals (n = 107) were examined for the presence of CCR5del32 mutation in the CCR5 gene. The CCR5del32 allele frequency in Russians and Tuvinians constituted 7.84 and 2%, respectively. Among HIV-1 infected individuals, two groups, of macrophage-tropic HIV-1 strain- and T-cell-tropic HIV-1 strain-infected were distinguished. The CCR5del32 allele frequency in the first group (6.45%) was lower than in the second one (8.73%). Statistical treatment of the HIV-1 infected individuals typing data showed that the difference in the CCR5del32 allele frequencies between the groups of sexually (macrophage-tropic) and parenterally (T-cell-tropic) infected individuals observed was within the limit of random deviation. © 2005 Pleiades Publishing, Inc.

UR - http://www.scopus.com/inward/record.url?scp=29144487048&partnerID=8YFLogxK

U2 - 10.1007/s11177-005-0230-6

DO - 10.1007/s11177-005-0230-6

M3 - Article

AN - SCOPUS:29144487048

VL - 41

SP - 1287

EP - 1290

JO - Russian Journal of Genetics

JF - Russian Journal of Genetics

SN - 1022-7954

IS - 11

ER -

ID: 115018720