Research output: Contribution to journal › Article › peer-review
Comparison CCR5del32 mutation in the CCR5 gene frequencies in Russians, Tuvinians, and in groups of HIV-infected individuals. / Apryatin, S. A.; Rakhmanaliev, E. R.; Nikolaeva, I. A.; Ruban, S. V.; Vazykhova, F. G.; Klimov, E. A.; Sulimova, G. E.; Sidorovich, I. G.
In: Russian Journal of Genetics, Vol. 41, No. 11, 01.11.2005, p. 1287-1290.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Comparison CCR5del32 mutation in the CCR5 gene frequencies in Russians, Tuvinians, and in groups of HIV-infected individuals
AU - Apryatin, S. A.
AU - Rakhmanaliev, E. R.
AU - Nikolaeva, I. A.
AU - Ruban, S. V.
AU - Vazykhova, F. G.
AU - Klimov, E. A.
AU - Sulimova, G. E.
AU - Sidorovich, I. G.
PY - 2005/11/1
Y1 - 2005/11/1
N2 - The 32-bp deletion (CCR5del32 mutation) in the CCR5 (chemokine (C-C motif) receptor 5) gene, encoding CCR5 chemokine receptor, is one of the factors determining natural resistance to human immunodeficiency virus (HIV-1) infection. In the present study, the samples of Russians (n = 102), Tuvinians (n = 50), and HIV-infected individuals (n = 107) were examined for the presence of CCR5del32 mutation in the CCR5 gene. The CCR5del32 allele frequency in Russians and Tuvinians constituted 7.84 and 2%, respectively. Among HIV-1 infected individuals, two groups, of macrophage-tropic HIV-1 strain- and T-cell-tropic HIV-1 strain-infected were distinguished. The CCR5del32 allele frequency in the first group (6.45%) was lower than in the second one (8.73%). Statistical treatment of the HIV-1 infected individuals typing data showed that the difference in the CCR5del32 allele frequencies between the groups of sexually (macrophage-tropic) and parenterally (T-cell-tropic) infected individuals observed was within the limit of random deviation. © 2005 Pleiades Publishing, Inc.
AB - The 32-bp deletion (CCR5del32 mutation) in the CCR5 (chemokine (C-C motif) receptor 5) gene, encoding CCR5 chemokine receptor, is one of the factors determining natural resistance to human immunodeficiency virus (HIV-1) infection. In the present study, the samples of Russians (n = 102), Tuvinians (n = 50), and HIV-infected individuals (n = 107) were examined for the presence of CCR5del32 mutation in the CCR5 gene. The CCR5del32 allele frequency in Russians and Tuvinians constituted 7.84 and 2%, respectively. Among HIV-1 infected individuals, two groups, of macrophage-tropic HIV-1 strain- and T-cell-tropic HIV-1 strain-infected were distinguished. The CCR5del32 allele frequency in the first group (6.45%) was lower than in the second one (8.73%). Statistical treatment of the HIV-1 infected individuals typing data showed that the difference in the CCR5del32 allele frequencies between the groups of sexually (macrophage-tropic) and parenterally (T-cell-tropic) infected individuals observed was within the limit of random deviation. © 2005 Pleiades Publishing, Inc.
UR - http://www.scopus.com/inward/record.url?scp=29144487048&partnerID=8YFLogxK
U2 - 10.1007/s11177-005-0230-6
DO - 10.1007/s11177-005-0230-6
M3 - Article
AN - SCOPUS:29144487048
VL - 41
SP - 1287
EP - 1290
JO - Russian Journal of Genetics
JF - Russian Journal of Genetics
SN - 1022-7954
IS - 11
ER -
ID: 115018720