Combined Immunization With Attenuated Live Influenza Vaccine and Chimeric Pneumococcal Recombinant Protein Improves the Outcome of Virus-Bacterial Infection in Mice

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Combined Immunization With Attenuated Live Influenza Vaccine and Chimeric Pneumococcal Recombinant Protein Improves the Outcome of Virus-Bacterial Infection in Mice. / Kramskaya, T. ; Leontieva, G. ; Desheva, Yu. ; Grabovskaya, K.; Gupalova, T. ; Rudenko, L.; Suvorov, A. .

в: PLoS ONE, Том 14, № 9, 0222148, 2019.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

BibTeX

@article{3a1a8acfae2e41c2b91e23ebe8f98bf3,

title = "Combined Immunization With Attenuated Live Influenza Vaccine and Chimeric Pneumococcal Recombinant Protein Improves the Outcome of Virus-Bacterial Infection in Mice",

abstract = "Influenza and its bacterial complications are a leading cause of morbidity and mortality worldwide. The effect of combined immunization with live influenza vaccine and recombinant chimeric pneumococcal protein in dual infection caused by influenza H1N1 and S. pneumoniae (serotype 3) has been studied. The combined vaccine consisted of the strain A/California/2009/38 (H1N1) pdm and chimeric recombinant protein PSPF composed of immunodominant fragments of the surface virulence factors of S. pneumoniae—PsaA, PspA, and Shr1875—associated with modified salmonella flagellin. Vaccinated mice were infected with the influenza virus 24 hours before or 24 hours after the onset of pneumococcal infection. The protective effect of combined vaccination was shown on both models of viral-bacterial infection.",

keywords = "Animals, Antibodies, Bacterial/immunology, Antigens, Bacterial/immunology, Coinfection/prevention & control, Disease Models, Animal, Female, Flagellin/immunology, Influenza Vaccines/administration & dosage, Mice, Mice, Inbred BALB C, Pneumococcal Infections/prevention & control, Pneumococcal Vaccines/administration & dosage, Recombinant Proteins/administration & dosage, Treatment Outcome, Vaccination, Vaccines, Attenuated, Vaccines, Combined, Virulence Factors/immunology",

author = "T. Kramskaya and G. Leontieva and Yu. Desheva and K. Grabovskaya and T. Gupalova and L. Rudenko and A. Suvorov",

note = "Kramskaya T, Leontieva G, Desheva Y, Grabovskaya K, Gupalova T, Rudenko L, et al. (2019) Combined immunization with attenuated live influenza vaccine and chimeric pneumococcal recombinant protein improves the outcome of virus-bacterial infection in mice. PLoS ONE 14(9): e0222148. https://doi.org/10.1371/journal.pone.0222148",

year = "2019",

doi = "10.1371/journal.pone.0222148",

language = "English",

volume = "14",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "9",

}

RIS

TY - JOUR

T1 - Combined Immunization With Attenuated Live Influenza Vaccine and Chimeric Pneumococcal Recombinant Protein Improves the Outcome of Virus-Bacterial Infection in Mice

AU - Kramskaya, T.

AU - Leontieva, G.

AU - Desheva, Yu.

AU - Grabovskaya, K.

AU - Gupalova, T.

AU - Rudenko, L.

AU - Suvorov, A.

N1 - Kramskaya T, Leontieva G, Desheva Y, Grabovskaya K, Gupalova T, Rudenko L, et al. (2019) Combined immunization with attenuated live influenza vaccine and chimeric pneumococcal recombinant protein improves the outcome of virus-bacterial infection in mice. PLoS ONE 14(9): e0222148. https://doi.org/10.1371/journal.pone.0222148

PY - 2019

Y1 - 2019

N2 - Influenza and its bacterial complications are a leading cause of morbidity and mortality worldwide. The effect of combined immunization with live influenza vaccine and recombinant chimeric pneumococcal protein in dual infection caused by influenza H1N1 and S. pneumoniae (serotype 3) has been studied. The combined vaccine consisted of the strain A/California/2009/38 (H1N1) pdm and chimeric recombinant protein PSPF composed of immunodominant fragments of the surface virulence factors of S. pneumoniae—PsaA, PspA, and Shr1875—associated with modified salmonella flagellin. Vaccinated mice were infected with the influenza virus 24 hours before or 24 hours after the onset of pneumococcal infection. The protective effect of combined vaccination was shown on both models of viral-bacterial infection.

AB - Influenza and its bacterial complications are a leading cause of morbidity and mortality worldwide. The effect of combined immunization with live influenza vaccine and recombinant chimeric pneumococcal protein in dual infection caused by influenza H1N1 and S. pneumoniae (serotype 3) has been studied. The combined vaccine consisted of the strain A/California/2009/38 (H1N1) pdm and chimeric recombinant protein PSPF composed of immunodominant fragments of the surface virulence factors of S. pneumoniae—PsaA, PspA, and Shr1875—associated with modified salmonella flagellin. Vaccinated mice were infected with the influenza virus 24 hours before or 24 hours after the onset of pneumococcal infection. The protective effect of combined vaccination was shown on both models of viral-bacterial infection.

KW - Animals

KW - Antibodies, Bacterial/immunology

KW - Antigens, Bacterial/immunology

KW - Coinfection/prevention & control

KW - Disease Models, Animal

KW - Female

KW - Flagellin/immunology

KW - Influenza Vaccines/administration & dosage

KW - Mice

KW - Mice, Inbred BALB C

KW - Pneumococcal Infections/prevention & control

KW - Pneumococcal Vaccines/administration & dosage

KW - Recombinant Proteins/administration & dosage

KW - Treatment Outcome

KW - Vaccination

KW - Vaccines, Attenuated

KW - Vaccines, Combined

KW - Virulence Factors/immunology

U2 - 10.1371/journal.pone.0222148

DO - 10.1371/journal.pone.0222148

M3 - Article

C2 - 31513620

VL - 14

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 9

M1 - 0222148

ER -

ID: 51619784