Combined Immunization With Attenuated Live Influenza Vaccine and Chimeric Pneumococcal Recombinant Protein Improves the Outcome of Virus-Bacterial Infection in Mice. / Kramskaya, T. ; Leontieva, G. ; Desheva, Yu. ; Grabovskaya, K.; Gupalova, T. ; Rudenko, L.; Suvorov, A. .
In: PLoS ONE, Vol. 14, No. 9, 0222148, 2019.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Combined Immunization With Attenuated Live Influenza Vaccine and Chimeric Pneumococcal Recombinant Protein Improves the Outcome of Virus-Bacterial Infection in Mice
AU - Kramskaya, T.
AU - Leontieva, G.
AU - Desheva, Yu.
AU - Grabovskaya, K.
AU - Gupalova, T.
AU - Rudenko, L.
AU - Suvorov, A.
N1 - Kramskaya T, Leontieva G, Desheva Y, Grabovskaya K, Gupalova T, Rudenko L, et al. (2019) Combined immunization with attenuated live influenza vaccine and chimeric pneumococcal recombinant protein improves the outcome of virus-bacterial infection in mice. PLoS ONE 14(9): e0222148. https://doi.org/10.1371/journal.pone.0222148
PY - 2019
Y1 - 2019
N2 - Influenza and its bacterial complications are a leading cause of morbidity and mortality worldwide. The effect of combined immunization with live influenza vaccine and recombinant chimeric pneumococcal protein in dual infection caused by influenza H1N1 and S. pneumoniae (serotype 3) has been studied. The combined vaccine consisted of the strain A/California/2009/38 (H1N1) pdm and chimeric recombinant protein PSPF composed of immunodominant fragments of the surface virulence factors of S. pneumoniae—PsaA, PspA, and Shr1875—associated with modified salmonella flagellin. Vaccinated mice were infected with the influenza virus 24 hours before or 24 hours after the onset of pneumococcal infection. The protective effect of combined vaccination was shown on both models of viral-bacterial infection.
AB - Influenza and its bacterial complications are a leading cause of morbidity and mortality worldwide. The effect of combined immunization with live influenza vaccine and recombinant chimeric pneumococcal protein in dual infection caused by influenza H1N1 and S. pneumoniae (serotype 3) has been studied. The combined vaccine consisted of the strain A/California/2009/38 (H1N1) pdm and chimeric recombinant protein PSPF composed of immunodominant fragments of the surface virulence factors of S. pneumoniae—PsaA, PspA, and Shr1875—associated with modified salmonella flagellin. Vaccinated mice were infected with the influenza virus 24 hours before or 24 hours after the onset of pneumococcal infection. The protective effect of combined vaccination was shown on both models of viral-bacterial infection.
KW - Animals
KW - Antibodies, Bacterial/immunology
KW - Antigens, Bacterial/immunology
KW - Coinfection/prevention & control
KW - Disease Models, Animal
KW - Female
KW - Flagellin/immunology
KW - Influenza Vaccines/administration & dosage
KW - Mice
KW - Mice, Inbred BALB C
KW - Pneumococcal Infections/prevention & control
KW - Pneumococcal Vaccines/administration & dosage
KW - Recombinant Proteins/administration & dosage
KW - Treatment Outcome
KW - Vaccination
KW - Vaccines, Attenuated
KW - Vaccines, Combined
KW - Virulence Factors/immunology
U2 - 10.1371/journal.pone.0222148
DO - 10.1371/journal.pone.0222148
M3 - Article
C2 - 31513620
VL - 14
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 9
M1 - 0222148
ER -
ID: 51619784